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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/advagg_css\/css__ce2QY63WIanKyr8eSq7eavr1XQRRmFD6ZSmwpyJi8lM__zXwFqpqmxrZOXXcd_TpBQpjuELbmIP9wBR5UuTDWAO4__YJWWMMdfCJuAFm5cUEp88OsodhO3ZA-2lzRfoBsSlk4.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003EAdministration of everolimus (combined with exemestane in real-world conditions extends progression-free survival in postmenopausal women with hormone receptor-positive advanced breast cancer. Data from the German Breast Cancer Treatment With Afinitor (Everolimus) and Exemestane for ER+ Women trial [BRAWO] are discussed in this article.\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003EOncology Clinical Trials\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EBreast Cancer\u003C\/li\u003E\u003C\/ul\u003E\u003Cul class=\u0022kwd-group clinical-trial\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003EOncology Clinical Trials\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EBreast Cancer\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EOncology\u003C\/li\u003E\u003C\/ul\u003E\u003Cp id=\u0022p-2\u0022\u003EAdministration of everolimus (EVE) combined with exemestane (EXE) in real-world conditions extends progression-free survival (PFS) in postmenopausal women with hormone receptor (HR)-positive advanced breast cancer. Data from the German Breast Cancer Treatment With Afinitor (Everolimus) and Exemestane for ER+ Women trial [BRAWO] were presented by Peter Fasching, MD, PhD, Universit\u00e4tsklinikum Erlangen Frauenklinik, Erlangen, Germany.\u003C\/p\u003E\u003Cp id=\u0022p-3\u0022\u003EThe data confirm findings from the pivotal phase 3 Everolimus in Combination With Exemestane in the Treatment of Postmenopausal Women With Estrogen Receptor Positive Locally Advanced or Metastatic Breast Cancer Who Are Refractory to Letrozole or Anastrozole trial [BOLERO-2; \u003Ca class=\u0022external-ref external-ref-type-clintrialgov\u0022 href=\u0022\/lookup\/external-ref?link_type=CLINTRIALGOV\u0026amp;access_num=NCT00863655\u0026amp;atom=%2Fspmdc%2F14%2F36%2F22.atom\u0022\u003ENCT00863655\u003C\/a\u003E], in which the combination of EVE and EXE more than doubled median PFS vs placebo in postmenopausal women with HR-positive advanced breast cancer whose disease is progressing after treatment with a nonsteroidal aromatase inhibitor.\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003EBRAWO is a noninterventional study of 3000 patients with advanced or metastatic HR-positive and HER2-negative breast cancer treated with EVE and EXE. As part of the study, data on routine clinical treatment with EVE 10 mg\/d and EXE 25 mg\/d were collected at about 400 sites throughout Germany. The results of the second preplanned interim analysis, 12 months after the inclusion of the 500th patient, were presented. The population of patients in BRAWO was broader than that for BOLERO-2, in that BRAWO could include patients treated previously with EXE and \u0026gt;1 previous line of chemotherapy in the palliative setting (\u003Ca id=\u0022xref-table-wrap-1-1\u0022 class=\u0022xref-table\u0022 href=\u0022#T1\u0022\u003ETable 1\u003C\/a\u003E).\u003C\/p\u003E\u003Cdiv id=\u0022T1\u0022 class=\u0022table pos-float\u0022\u003E\u003Cdiv class=\u0022table-inline\u0022\u003E\u003Cdiv class=\u0022callout\u0022\u003E\u003Cspan\u003EView this table:\u003C\/span\u003E\u003Cul class=\u0022callout-links\u0022\u003E\u003Cli class=\u00220 first\u0022\u003E\u003Ca href=\u0022\/\u0022 class=\u0022table-expand-inline\u0022 data-table-url=\u0022\/highwire\/markup\/12101\/expansion?postprocessors=highwire_figures%2Chighwire_math%2Chighwire_inline_linked_media%2Chighwire_embed\u0026amp;table-expand-inline=1\u0022 html=\u00221\u0022 fragment=\u0022#\u0022 external=\u00221\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView inline\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00221\u0022\u003E\u003Ca href=\u0022\/highwire\/markup\/12101\/expansion?width=1000\u0026amp;height=500\u0026amp;iframe=true\u0026amp;postprocessors=highwire_figures%2Chighwire_math%2Chighwire_inline_linked_media\u0022 class=\u0022colorbox colorbox-load table-expand-popup\u0022 rel=\u0022gallery-fragment-tables\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView popup\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00222 last\u0022\u003E\u003Ca href=\u0022\/highwire\/powerpoint\/12101\u0022 class=\u0022highwire-figure-link highwire-figure-link-ppt\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload powerpoint\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cdiv class=\u0022table-caption\u0022\u003E\u003Cspan class=\u0022table-label\u0022\u003ETable 1.\u003C\/span\u003E \n            \u003Cp id=\u0022p-5\u0022 class=\u0022first-child\u0022\u003EBRAWO: Inclusion Criteria and Study Characteristics\u003C\/p\u003E\n         \u003Cdiv class=\u0022sb-div caption-clear\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cp id=\u0022p-8\u0022\u003EThe median time from primary diagnosis was 7.2 years and the median time from first diagnosis to recurrence or metastasis was 2.7 years. Compared with BOLERO-2, patients in BRAWO were older (66 vs 62 years) and fewer had ECOG performance status 0 (43.6% vs 60%). The percentage of patients with visceral metastasis at baseline was comparable between the 2 studies (53.7% in BRAWO and 58.0% in BOLERO-2).\u003C\/p\u003E\u003Cp id=\u0022p-9\u0022\u003EIn BRAWO, 86.7% of patients received 10 mg of EVE at the start of therapy. Most patients received EVE and EXE as first- (26.2%) or second-line treatment (28.8%) for advanced disease; 18.8% received it as third-line treatment and 26.2% as fourth- or later-line treatment. There were 445 patients (89.0%) who switched to EVE plus EXE because of disease progression on a prior therapy. Among the patients who received EVE plus EXE as first- or second-line therapy in the advanced setting, the most common last prior antineoplastic therapies were letrozole and anastrozole.\u003C\/p\u003E\u003Cp id=\u0022p-10\u0022\u003EThe median PFS was 8.0 months. For the 131 patients who received EVE plus EXE as first-line treatment in the advanced setting, the median PFS was 10.1 months. These values were consistent with the median PFS values achieved in BOLERO-2 (7.8 months in the overall study population and 11.5 months in those who received the combination as first- or second-line treatment), said Prof Fasching.\u003C\/p\u003E\u003Cp id=\u0022p-11\u0022\u003EAdverse events in BRAWO were consistent with those previously reported with EVE and EXE in advanced breast cancer. The percentage of patients with stomatitis was lower in BRAWO (39.8%) compared with BOLERO-2 (59%), which was probably related to the almost 87% of patients in BRAWO who received prophylactic treatment for stomatitis, noted Prof Fasching. Other common adverse events of any grade in BRAWO were fatigue (15.6%), diarrhea (13.2%), dyspnea (13.0%), nausea (12.0%), and decreased appetite (10.4%). Nearly one-half of patients (48.1%) required EVE dose reduction.\u003C\/p\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2014 MD Conference Express\u00ae\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/14\/36\/22.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzopyp\u0022\u003E\u003C\/script\u003E\n\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_tables.js?nzopyp\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}