PT - JOURNAL ARTICLE AU - Rizzo, Toni ED - Paul, Carle TI - ESTEEM 2: Apremilast Significantly Reduced Psoriasis Severity Throughout 16 Weeks DP - 2014 Dec 01 TA - MD Conference Express PG - 15--16 VI - 14 IP - 37 4099 - http://mdc.sagepub.com/content/14/37/15.short 4100 - http://mdc.sagepub.com/content/14/37/15.full AB - Apremilast, an oral phosphodiesterase 4 inhibitor that works intracellularly to regulate inflammatory mediators, has been tested in the Efficacy and Safety Trial Evaluating the Effects of Apremilast in Psoriasis (ESTEEM) program, which consists of 2 trials: ESTEEM 1 [NCT01194219] and ESTEEM 2 [NCT01232283]. This article presents the 52-week results of the ESTEEM 2 trial.