NS, not significant.*P < .0001 from baseline.Adapted from Rademaker M et al. Isotretinoin 5 mg daily for low-grade adult acne vulgaris—a placebo-controlled, randomized double-blind study. J Eur Acad Dermatol Venereol. 2013;28:747–754. With permission from European Academy of Dermatology and Venereology