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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/cdn\/css\/http\/css_Xg7z6oCTVgud_Q0huYz9x9iiD5H_2YPSJ5z2ZViSWdY.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003ELow-dose isotretinoin reduced the number of acne lesions in adult patients with acne vulgaris beginning at 4 weeks and continuing through 32 weeks, with 40% of patients remaining acne free for 3 years. This article discusses data from an unpublished follow-up study that evaluated low-dose isotretinoin for the treatment of adult acne.\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003ESkin Diseases\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EDermatology Clinical Trials\u003C\/li\u003E\u003C\/ul\u003E\u003Cul class=\u0022kwd-group clinical-trial\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003ESkin Diseases\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EDermatology Clinical Trials\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EDermatology\u003C\/li\u003E\u003C\/ul\u003E\u003Cp id=\u0022p-2\u0022\u003ELow-dose isotretinoin reduced the number of acne lesions in adult patients with acne vulgaris beginning at 4 weeks and continuing through 32 weeks, with 40% of patients remaining acne free for 3 years. Marius Rademaker, MD, Waikato Hospital, Hamilton West, New Zealand, presented data from an unpublished follow-up study that evaluated low-dose isotretinoin for the treatment of adult acne.\u003C\/p\u003E\u003Cp id=\u0022p-3\u0022\u003EAdult acne affects up to 50% of the population. Conventional treatment of adult acne is frequently ineffective or unacceptable to patients, however; there is a high dissatisfaction rate due to a slow response, poor total clearance of acne, and a high relapse rate [Rademaker M et al. \u003Cem\u003EJ Eur Acad Dermatol Venereol\u003C\/em\u003E. 2013]. In addition, few studies have evaluated topical retinoids, systemic antibiotics, or isotretinoin in adults. The purpose of this study was to evaluate the effect of low-dose isotretinoin on low-grade adult acne vulgaris.\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003EIn this double-blind, parallel-group study, 60 patients aged 25 to 55 years with low-grade adult acne vulgaris were randomly assigned to receive 5 mg\/d of isotretinoin or placebo for 16 weeks, followed by an open-label period of isotretinoin treatment for 16 weeks. Follow-up continued for an additional 10 weeks after treatment ended. The primary end point of the study was difference in acne lesion count and disability score at week 16. The secondary end points included the differences in acne lesion count and disability score at week 32 and at the final follow-up visit.\u003C\/p\u003E\u003Cp id=\u0022p-5\u0022\u003EThe number of acne lesions significantly decreased in the isotretinoin arm beginning at week 4 and peaked at week 32 (\u003Cem\u003EP\u003C\/em\u003E \u0026lt; .0001), and it was maintained throughout the study, including during the off-treatment follow-up period (\u003Ca id=\u0022xref-fig-1-1\u0022 class=\u0022xref-fig\u0022 href=\u0022#F1\u0022\u003EFigure 1\u003C\/a\u003E).\u003C\/p\u003E\u003Cdiv id=\u0022F1\u0022 class=\u0022fig pos-float  odd\u0022\u003E\u003Cdiv class=\u0022highwire-figure\u0022\u003E\u003Cdiv class=\u0022fig-inline-img-wrapper\u0022\u003E\u003Cdiv class=\u0022fig-inline-img\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/14\/37\/13.2\/F1.large.jpg?width=800\u0026amp;height=600\u0026amp;carousel=1\u0022 title=\u0022Low-Dose Isotretinoin Treatment for Adult Acne\u0022 class=\u0022fragment-images colorbox-load\u0022 rel=\u0022gallery-fragment-images-1789166450\u0022 data-figure-caption=\u0022Low-Dose Isotretinoin Treatment for Adult Acne\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003E\u003Cimg class=\u0022fragment-image\u0022 alt=\u0022Figure 1.\u0022 src=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/14\/37\/13.2\/F1.medium.gif\u0022\/\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cul class=\u0022highwire-figure-links inline\u0022\u003E\u003Cli class=\u00220 first\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/14\/37\/13.2\/F1.large.jpg?download=true\u0022 class=\u0022highwire-figure-link highwire-figure-link-download\u0022 title=\u0022Download Figure 1.\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload figure\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00221\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/14\/37\/13.2\/F1.large.jpg\u0022 class=\u0022highwire-figure-link highwire-figure-link-newtab\u0022 target=\u0022_blank\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EOpen in new tab\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00222 last\u0022\u003E\u003Ca href=\u0022\/highwire\/powerpoint\/12112\u0022 class=\u0022highwire-figure-link highwire-figure-link-ppt\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload powerpoint\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003Cdiv class=\u0022fig-caption attrib\u0022\u003E\u003Cspan class=\u0022fig-label\u0022\u003EFigure 1.\u003C\/span\u003E \n            \u003Cp id=\u0022p-6\u0022 class=\u0022first-child\u0022\u003ELow-Dose Isotretinoin Treatment for Adult Acne\u003C\/p\u003E\n         \u003Cq class=\u0022attrib\u0022 id=\u0022attrib-1\u0022\u003ENS, not significant.\u003C\/q\u003E\u003Cq class=\u0022attrib\u0022 id=\u0022attrib-2\u0022\u003E*\u003Cem\u003EP\u003C\/em\u003E \u0026lt; .0001 from baseline.\u003C\/q\u003E\u003Cq class=\u0022attrib\u0022 id=\u0022attrib-3\u0022\u003EAdapted from Rademaker M et al. Isotretinoin 5 mg daily for low-grade adult acne vulgaris\u2014a placebo-controlled, randomized double-blind study. \u003Cem\u003EJ Eur Acad Dermatol Venereol\u003C\/em\u003E. 2013;28:747\u2013754. With permission from European Academy of Dermatology and Venereology\u003C\/q\u003E\u003Cdiv class=\u0022sb-div caption-clear\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cp id=\u0022p-7\u0022\u003EIn a follow-up study, 60% of patients reported recurrence of at least one acne lesion at a mean time of 9.1 months. Their acne, however, was less severe at recurrence than what they had experienced prior to isotretinoin treatment. As a result, 60% of patients received further treatment for their acne, including topical retinoids, doxycycline, or isotretinoin. Isotretinoin was restarted by 48% of patients for a median of 6 months, and they continued the medication for a mean of 12.4 months. At the time of the follow-up study, 21% of patients were still taking isotretinoin with a median dose of 10 mg twice per week.\u003C\/p\u003E\u003Cp id=\u0022p-8\u0022\u003EIn conclusion, Prof Rademaker stated that, in his opinion, the data from this study suggest that treatment of adult acne with low-dose isotretinoin is effective, because it improves acne by week 4 with continuous improvement up to week 32. In addition, 40% of patients remained acne free by 3 years, and patients reported a very high level of satisfaction. Isotretinoin was well tolerated with few adverse events.\u003C\/p\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2014 MD Conference Express\u00ae\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/14\/37\/13.2.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_figures.js?nzop1d\u0022\u003E\u003C\/script\u003E\n\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzop1d\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}