PT  - JOURNAL ARTICLE
AU  - Buckley, Rita
ED  - Roozekrans, Margot
TI  - BK Channel Blocker Rapidly Reverses OIRD
DP  - 2014  01
TA  - MD Conference Express
PG  - 13--14
VI  - 14
IP  - 40
4099  - http://mdc.sagepub.com/content/14/40/13.2.short
4100  - http://mdc.sagepub.com/content/14/40/13.2.full
AB  - A pharmacokinetic/pharmacodynamic (PK/PD) modeling study on the effect of the BK channel blocker GAL021 found that it produced rapid reversal of opioid-induced respiratory depression (OIRD) in a population of healthy male volunteers. This article discusses a study assessing whether GAL21 stimulates breathing in OIRD and evaluated its safety in a proof-of-concept, double-blind crossover study on isohypercapnic ventilation and a subsequent double-blind exploratory study on poikilocapnic ventilation and nonrespiratory end points.