RT Journal Article
SR Electronic
A1 Kuznar, Wayne
T1 GR Agonist Improves Responses in RA
JF MD Conference Express
YR 2014
FD SAGE Publications
VO 14
IS 51
SP 8
OP 9
DO 10.1177/155989771451004
UL http://mdc.sagepub.com/content/14/51/8.abstract
AB The glucocorticoid receptor (GR) regulates genes that control development and metabolism and the immune response. A dissociated agonist of the glucocorticoid receptor (DAGR) is a nonsteroidal ligand of the GR that has both partial agonist and antagonistic properties. This article discusses a phase 2 trial that compared response rates between a DAGR and prednisone in patients with rheumatoid arthritis.