<?xml version='1.0' encoding='UTF-8'?><xml><records><record><source-app name="HighWire" version="7.x">Drupal-HighWire</source-app><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Hitt Nichols, Emma</style></author></authors><secondary-authors><author><style face="normal" font="default" size="100%">Grottke, Oliver</style></author></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">PCC Reverses Dabigatran-Associated Bleeding in Polytrauma Model</style></title><secondary-title><style face="normal" font="default" size="100%">MD Conference Express</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2014</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2014-12-01 00:00:00</style></date></pub-dates></dates><pages><style  face="normal" font="default" size="100%">22-22</style></pages><abstract><style  face="normal" font="default" size="100%">In a porcine polytrauma model with dabigatran-associated bleeding, bleeding rates were reduced and 100% survival rates were achieved by infusion with 4-factor prothrombin complex concentrate. The effect of 4-factor prothrombin complex concentrate was further enhanced by the addition of tranexamic acid and fibrinogen. However, tranexamic acid and fibrinogen alone did not reduce blood loss or improve survival rates compared with placebo.</style></abstract><number><style face="normal" font="default" size="100%">55</style></number><volume><style face="normal" font="default" size="100%">14</style></volume></record></records></xml>