RT Journal Article
SR Electronic
A1 Vinall, Maria
T1 Activity of Lenalidomide in MDS Tied to Degradation of CSNK1A1
JF MD Conference Express
YR 2014
FD SAGE Publications
VO 14
IS 55
SP 7
OP 8
DO 10.1177/1559897714568636
UL http://mdc.sagepub.com/content/14/55/7.abstract
AB This study identifies a potential mechanism of action for lenalidomide in del(5q) myelodysplastic syndrome and identifies a single nonconserved amino acid in mice and humans that determines lenalidomide susceptibility. The results may facilitate the development of improved preclinical models and reinforces the importance of haploinsufficient genes in the pathogenesis and treatment of disease.