RT Journal Article
SR Electronic
A1 Vinall, Maria
T1 JAK2-STAT3 Signaling Implicated in the Regulation of Hepatic TPO Production
JF MD Conference Express
YR 2014
FD SAGE Publications
VO 14
IS 55
SP 4
OP 5
DO 10.1177/1559897715570609
UL http://mdc.sagepub.com/content/14/55/4.abstract
AB New research findings can now explain the complete pathway for the regulation of thrombopoietin production, which regulates the production of platelets. Platelets lacking sialic acid due to aging are removed by the Ashwell-Morell receptor. The signaling pathways Janus kinase 2 and signal transducer and activator of transcription 3 then stimulates the production of thrombopoietin within the hepatocyte nucleus.