PT - JOURNAL ARTICLE AU - Hoyle, Brian ED - DeBaun, Michael R. ED - Hebbel, Robert TI - Advances and Challenges in Sickle Cell Anemia DP - 2014 01 TA - MD Conference Express PG - 2--3 VI - 14 IP - 55 4099 - http://mdc.sagepub.com/content/14/55/2.short 4100 - http://mdc.sagepub.com/content/14/55/2.full AB - Sickle cell disease can lead to stroke, which affects about 40% of those with the disease by mid-adolescence. The cognitive damage can lessen IQ and diminish quality of life. Research is leading to helpful strategies, and has also revealed details of the arterial accumulation of the affected red blood cells.