RT Journal Article SR Electronic A1 Hoyle, Brian T1 Advances and Challenges in Sickle Cell Anemia JF MD Conference Express YR 2014 FD SAGE Publications VO 14 IS 55 SP 2 OP 3 DO 10.1177/1559897715570839 UL http://mdc.sagepub.com/content/14/55/2.abstract AB Sickle cell disease can lead to stroke, which affects about 40% of those with the disease by mid-adolescence. The cognitive damage can lessen IQ and diminish quality of life. Research is leading to helpful strategies, and has also revealed details of the arterial accumulation of the affected red blood cells.