Figure 1.

mRNA Expressions

Error bars represent SEM.

4-OH-TAM, 4-hydrotamoxifen; E2, estradiol; ER, estrogen receptor; OnME₂, zero nano molar estradiol; SEM, standard error of the mean; SNP, single-nucleotide polymorphisms; V, variant; WT, wild type.

*P < .05 vs OnME₂.

**P < .01 vs OnME₂.

Adapted from Cancer Discovery, Copyright 2013;3:812–825, Ingle JN et al, Selective estrogen receptor modulators and pharmacogenomic variation in ZNF423 regulation of BRCA1 expression: individualized breast cancer prevention. With permission from AACR.