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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/advagg_css\/css__ce2QY63WIanKyr8eSq7eavr1XQRRmFD6ZSmwpyJi8lM__zXwFqpqmxrZOXXcd_TpBQpjuELbmIP9wBR5UuTDWAO4__YJWWMMdfCJuAFm5cUEp88OsodhO3ZA-2lzRfoBsSlk4.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003EThis article reviews data on the feasibility and accuracy of sentinel node biopsy after neoadjuvant chemotherapy, and discusses the latest advances in breast reconstruction following mastectomy, as well as the use of preoperative MRI for the detection of multicentric disease in women diagnosed with breast cancer.\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003EAdjuvant\/Neoadjuvant Therapy\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EBreast Cancer\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ERadiology\u003C\/li\u003E\u003C\/ul\u003E\u003Cdiv class=\u0022section\u0022 id=\u0022sec-1\u0022\u003E\n         \u003Ch2 class=\u0022\u0022\u003ESentinel Node Biopsy: Before or After Neoadjuvant Chemotherapy?\u003C\/h2\u003E\n         \u003Cp id=\u0022p-2\u0022\u003ENeoadjuvant chemotherapy (NACT) has been found to have equivalent outcomes to adjuvant chemotherapy for breast cancer in terms of disease-free survival (DFS) and overall survival (OS). Additionally, NACT has been shown to increase the rate of breast-conserving surgery (BCS) without adversely effecting DFS or OS. However, the role of sentinel node biopsy (SNB) after NACT that may potentially sterilize the axilla remains unclear. Eleftherios Mamounas, MD, MPH, Northeastern Ohio Medical University, Rootstown, Ohio, USA, reviewed data on the feasibility and accuracy of SNB after NACT.\u003C\/p\u003E\n         \u003Cp id=\u0022p-3\u0022\u003EPooled data from single-institution studies of SNB after NACT show considerable variability in sentinel lymph node (SLN) identification and false-negative rates due to small numbers of subjects. A meta-analysis of 24 single and multicenter studies of SNB after NACT in 1799 subjects with early-stage breast cancer reported a pooled SLN identification rate of 89.6% (95% CI, 86.0 to 92.3) with moderate heterogeneity and a false-negative rate of 8.4% (95% CI, 6.4 to 10.9) with no significant heterogeneity [Kelly AM et al. \u003Cem\u003EAcad Radiol\u003C\/em\u003E 2009]. The authors concluded that SNB is a reliable tool for planning treatment after NACT.\u003C\/p\u003E\n         \u003Cp id=\u0022p-4\u0022\u003EA study of SNB after NACT (n=575) versus SNB upfront (n=3171) reported SLN identification rates of 97.4% versus 98.7% (p=0.017), false-negative rates of 5.9% versus 4.1% (p=0.39), and positive node rates of 12.7% versus 19.0% (T1; p=0.2), 20.5% versus 36.5% (T2; p\u0026lt;0.0001), and 30.4% versus 51.4% (T3; p=0.04) [Hunt KK et al. \u003Cem\u003EAnn Surg\u003C\/em\u003E 2009]. The investigators concluded that SNB after NACT is as accurate as SNB before NACT, results in fewer positive SLNs, and decreases unnecessary axillary dissections.\u003C\/p\u003E\n         \u003Cp id=\u0022p-5\u0022\u003EProponents of SNB before NACT contend that this approach provides information on SLN status without the confounding effects of NACT and that SLN patients can avoid axillary dissection. Dr. Mamounas argued that although this strategy may benefit patients with negative SLNs, it is not useful for most NACT candidates. This approach also does not take advantage of the downstaging benefit of NACT on nodes and requires two surgical procedures for most patients.\u003C\/p\u003E\n         \u003Cp id=\u0022p-6\u0022\u003EDr. Mamounas concluded that SNB before NACT does not offer clinical advantages and reduces the number of patients who could benefit from the down-staging effect of NACT on the axillary nodes. SNB after NACT is feasible and accurate with similar performance as SNB before NACT. By performing SNB after NACT, up to 40% of patients who present with involved axillary nodes may be spared axillary dissection. Caution is required for patients who present with clinically or pathologically involved nodes before NACT.\u003C\/p\u003E\n      \u003C\/div\u003E\u003Cdiv class=\u0022section\u0022 id=\u0022sec-2\u0022\u003E\n         \u003Ch2 class=\u0022\u0022\u003EImplant Breast Reconstruction\u003C\/h2\u003E\n         \u003Cp id=\u0022p-7\u0022\u003EWomen undergoing mastectomy are increasingly choosing to undergo implant breast reconstruction. Over the past 5 years, next-generation silicone implants, acellular dermal matrices, and fat grafting have expanded the options available to patients [Pusic AL. SABCS 2012 (abstr ES6\u20132)]. Additionally, indications for postmastectomy radiation are increasing, with implications for long-term patient satisfaction with implant reconstruction. Andrea L. Pusic, MD, MHS, Memorial Sloan-Kettering Cancer Center, New York, New York, USA, discussed the latest advances in breast reconstruction following mastectomy.\u003C\/p\u003E\n         \u003Cp id=\u0022p-8\u0022\u003ENew options in breast reconstruction include the fifth generation cohesive gel implant made of cross-linked silicone and direct-to-implant surgery performed at the same time as mastectomy. Dr. Pusic emphasized the importance of patient-reported outcomes to evaluate patient satisfaction, quality of life (QoL), and adverse effects of these and other breast reconstruction methods. In collaboration with her colleagues, Dr. Pusic developed the BREAST-Q patient-reported outcome measure for use after breast surgery [Pusic AL et al. \u003Cem\u003EPlast Reconstr Surg\u003C\/em\u003E 2009]. The BREAST-Q framework consists of six domains, each with a separate scale: satisfaction with breasts; outcomes; care; and physical, psychosocial, and sexual well-being (\u003Ca id=\u0022xref-fig-1-1\u0022 class=\u0022xref-fig\u0022 href=\u0022#F1\u0022\u003EFigure 1\u003C\/a\u003E). By measuring patient-reported outcomes, the BREAST-Q can support an evidence-based approach to breast reconstruction surgery.\u003C\/p\u003E\n         \u003Cdiv id=\u0022F1\u0022 class=\u0022fig pos-float  odd\u0022\u003E\u003Cdiv class=\u0022highwire-figure\u0022\u003E\u003Cdiv class=\u0022fig-inline-img-wrapper\u0022\u003E\u003Cdiv class=\u0022fig-inline-img\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/12\/20\/16\/F1.large.jpg?width=800\u0026amp;height=600\u0026amp;carousel=1\u0022 title=\u0022BREAST-Q conceptual framework.\u0022 class=\u0022fragment-images colorbox-load\u0022 rel=\u0022gallery-fragment-images-1361367492\u0022 data-figure-caption=\u0022BREAST-Q conceptual framework.\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003E\u003Cimg class=\u0022fragment-image\u0022 alt=\u0022Figure 1.\u0022 src=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/12\/20\/16\/F1.medium.gif\u0022\/\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cul class=\u0022highwire-figure-links inline\u0022\u003E\u003Cli class=\u00220 first\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/12\/20\/16\/F1.large.jpg?download=true\u0022 class=\u0022highwire-figure-link highwire-figure-link-download\u0022 title=\u0022Download Figure 1.\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload figure\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00221\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/12\/20\/16\/F1.large.jpg\u0022 class=\u0022highwire-figure-link highwire-figure-link-newtab\u0022 target=\u0022_blank\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EOpen in new tab\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00222 last\u0022\u003E\u003Ca href=\u0022\/highwire\/powerpoint\/14535\u0022 class=\u0022highwire-figure-link highwire-figure-link-ppt\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload powerpoint\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003Cdiv class=\u0022fig-caption attrib\u0022\u003E\u003Cspan class=\u0022fig-label\u0022\u003EFigure 1.\u003C\/span\u003E \n               \u003Cp id=\u0022p-9\u0022 class=\u0022first-child\u0022\u003EBREAST-Q conceptual framework.\u003C\/p\u003E\n            \u003Cq class=\u0022attrib\u0022 id=\u0022attrib-1\u0022\u003EReproduced with permission from Wolters Kluwer Health. Pusic A et al. Plastic and Reconstructive Surgery 2009; 124(2): 345\u2013353.\u003C\/q\u003E\u003Cdiv class=\u0022sb-div caption-clear\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\n         \u003Cp id=\u0022p-10\u0022\u003EA recent analysis of breast reconstruction trends revealed that over the last decade implant reconstruction rates have increased by an average of 11% per year, while autologous reconstruction rates have remained the same (p\u0026lt;0.01) [Albornoz CR et al. \u003Cem\u003EPlast Reconstr Surg\u003C\/em\u003E 2013]. Another trend is the expansion of indications for radiation therapy, which negatively impacts patient satisfaction with physical, QoL, and breast reconstruction outcomes [Albornoz CR et al. ISOQOL 2012]. New devices and surgical techniques may offer benefit but should be evaluated from both the clinician and patient perspectives. The BREAST-Q can facilitate quantification of patient satisfaction, QoL, and adverse effects.\u003C\/p\u003E\n      \u003C\/div\u003E\u003Cdiv class=\u0022section\u0022 id=\u0022sec-3\u0022\u003E\n         \u003Ch2 class=\u0022\u0022\u003EPreoperative Breast MRI\u003C\/h2\u003E\n         \u003Cp id=\u0022p-11\u0022\u003EIsmail Jatoi, MD, PhD, University of Texas Health Science Center, San Antonio, Texas, USA, discussed the use of preoperative MRI for the detection of multicentric disease in women diagnosed with breast cancer. The presence of multicentric or contralateral disease is an important consideration in the selection of BCS versus mastectomy.\u003C\/p\u003E\n         \u003Cp id=\u0022p-12\u0022\u003EMulticentric breast cancer generally is detected by clinical breast examination, mammography, and ultrasound. A systematic review and meta-analysis of 50 studies showed that preoperative breast MRI detected additional disease foci in 20% of women and contralateral disease in 5.5% [Plana MN et al. \u003Cem\u003EEur Radiol\u003C\/em\u003E 2012]. Early studies have documented the presence of occult tumor foci in addition to the primary tumor in 54% to 63% of cases [Qualheim RE et al. \u003Cem\u003ECancer\u003C\/em\u003E 1957; Holland R et al. \u003Cem\u003ECancer\u003C\/em\u003E 1985; Vaidya JS et al. \u003Cem\u003EBr J Cancer\u003C\/em\u003E 1996].\u003C\/p\u003E\n         \u003Cp id=\u0022p-13\u0022\u003EThe possibility of multicentric disease has been a deterrent to performing BCS as an alternative to mastectomy. Two randomized trials assessed the impact of preoperative breast MRI on reoperation rates and demonstrate differing results. The COMICE trial in patients randomized to MRI versus no MRI reported reoperation rates of approximately 19% in both arms (OR, 0.96; p=0.77) [Turnbull L et al. \u003Cem\u003ELancet\u003C\/em\u003E 2010]. The MONET trial of patients with nonpalpable breast cancers randomized to MRI versus no MRI found reoperation rates of 34% versus 12% (p=0.008) [Peters NH et al. \u003Cem\u003EEur J Cancer\u003C\/em\u003E 2011].\u003C\/p\u003E\n         \u003Cp id=\u0022p-14\u0022\u003EStudies of the effect of preoperative MRI versus no MRI on local recurrences have had mixed results [Fischer U et al. \u003Cem\u003EEur Radiol\u003C\/em\u003E 2004; Hwang N et al. \u003Cem\u003EAnn Surg Oncol\u003C\/em\u003E 2009; Solin LJ et al. \u003Cem\u003EJ Clin Oncol\u003C\/em\u003E 2008]. The Solin study found no difference between local failure rates according to the use of breast MRI at the time of initial diagnosis and evaluation for BCS with radiation.\u003C\/p\u003E\n         \u003Cp id=\u0022p-15\u0022\u003EBreast MRI is potentially useful in the following situations: screening in certain women at increased risk for breast cancer, detection of primary tumor in women with malignant axillary adenopathy and a negative mammogram, monitoring response to neoadjuvant therapy, evaluating nipple discharge, and evaluating breast implants.\u003C\/p\u003E\n         \u003Cp id=\u0022p-16\u0022\u003EDr. Jatoi said that routine preoperative breast MRI should not be recommended because it does not reduce risk of reoperation following BCS, does not lower risk of local recurrence, may delay surgery, may increase patient anxiety, may increase risk of unnecessary breast biopsies\/imaging, may unnecessarily increase mastectomy rates, and may unnecessarily increase contralateral mastectomy rates. Preoperative MRI can be useful for identifying additional lesions apart from the primary tumor. These lesions can be adequately treated with radiotherapy and systemic therapies or may have no clinical significance.\u003C\/p\u003E\n      \u003C\/div\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2013 MD Conference Express\u00ae\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/12\/20\/16.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_figures.js?nzo4we\u0022\u003E\u003C\/script\u003E\n\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzo4we\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}