RT Journal Article
SR Electronic
A1 Nichols, Emma Hitt
T1 Neoadjuvant Chemotherapy in Women 35 and Under
JF MD Conference Express
YR 2013
FD SAGE Publications
VO 12
IS 20
SP 13
OP 14
DO 10.1177/155989771220010
UL http://mdc.sagepub.com/content/12/20/13.abstract
AB Evidence suggests that breast cancer in younger women may be clinically and etiologically distinct from older women [Bleyer A et al. Nat Rev Cancer 2010]. Breast cancer in young women demonstrates a worse prognosis and a more aggressive phenotype, higher proportions of high-grade and later-stage tumors, lower estrogen receptor positivity, and, in some studies, higher expression of human epidermal growth factor receptor 2 [Bleyer A et al. Nat Rev Cancer 2010; Gnerlich JL et al. J Am Coll Surg 2009]. This article presents data on the response to neoadjuvant chemotherapy in women with breast cancer who are aged =35 years compared with older women.