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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/advagg_css\/css__ce2QY63WIanKyr8eSq7eavr1XQRRmFD6ZSmwpyJi8lM__zXwFqpqmxrZOXXcd_TpBQpjuELbmIP9wBR5UuTDWAO4__YJWWMMdfCJuAFm5cUEp88OsodhO3ZA-2lzRfoBsSlk4.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003EThe international standard for radiotherapy after primary surgery for early breast cancer has been a total dose of 50 Gy administered in 25 small daily fractions over 5 weeks. However, the randomized UK Standardisation of Breast Radiotherapy [START] trials indicate that a lower total dose delivered in fewer larger fractions is likely to be safe and effective [START Trialists\u0027 Group. \u003Cem\u003ELancet\u003C\/em\u003E 2008; \u003Cem\u003ELancet Oncol\u003C\/em\u003E 2008]. This article presents the 10-year follow-up results of the UK START trials, which tested 13- and 15-fraction regimens in women with completely excised early breast cancer (T1\u20133, N0\u20131, M0).\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003ERadiology\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EOncology Clinical Trials\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ERadiation Therapy\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EBreast Cancer\u003C\/li\u003E\u003C\/ul\u003E\u003Cp id=\u0022p-2\u0022\u003EThe international standard for radiotherapy after primary surgery for early breast cancer has been a total dose of 50 Gy administered in 25 small daily fractions over 5 weeks. However, the randomized UK Standardisation of Breast Radiotherapy [START] trials indicate that a lower total dose delivered in fewer larger fractions is likely to be safe and effective [START Trialists\u0027 Group. \u003Cem\u003ELancet\u003C\/em\u003E 2008; \u003Cem\u003ELancet Oncol\u003C\/em\u003E 2008]. The 5-year results of the START B trial suggested that 40 Gy in 15 fractions is as safe as and noninferior in terms of tumor control to 50 Gy in 25 fractions [START Trialists\u0027 Group. \u003Cem\u003ELancet\u003C\/em\u003E 2008]. John Yarnold, MBBS, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, Sutton, United Kingdom, presented the 10-year follow-up results of the UK START trials, which tested 13- and 15-fraction regimens in women with completely excised early breast cancer (T1\u20133, N0\u20131, M0). The START trials were coordinated by the Clinical Trials and Statistics Unit at The Institute of Cancer Research and funded by Cancer Research UK, the UK Medical Research Council, and the UK Department of Health.\u003C\/p\u003E\u003Cp id=\u0022p-3\u0022\u003EIn Trial A, 2236 patients were randomized to receive 50 Gy in 25 fractions (n=749), 39.0 Gy in 13 fractions (n=737), or 41.6 Gy in 13 fractions (n=750), all given for 5 weeks [START Trialists\u0027 Group. \u003Cem\u003ELancet Oncol\u003C\/em\u003E 2008]. In Trial B, 2215 patients were randomized to 50 Gy in 25 fractions for 5 weeks (n=1105) or 40 Gy in 15 fractions for 3 weeks (n=1110) [START Trialists\u0027 Group. \u003Cem\u003ELancet\u003C\/em\u003E 2008]. The primary endpoint was local-regional relapse. Secondary endpoints included effects on normal tissue, disease-free survival, and overall survival. The median follow-up was 9.3 years for Trial A and 9.9 years for Trial B.\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003EIn Trial A, the 10-year rate of patients with local-regional relapse was 7.4% (95% CI, 5.5 to 10.0) after 50 Gy, 6.3% (95% CI, 4.7 to 8.5) after 41.6 Gy, and 8.8% (95% CI, 6.7 to 11.4) after 39 Gy. The hazard ratio (HR) for 41.6 versus 50 Gy was 0.91 (95% CI, 0.59 to 1.38) and for 39 versus 50 Gy was 1.18 (95% CI, 0.79 to 1.76). In Trial B, the percentage of patients with a local-regional relapse was 5.5% (95% CI, 4.2 to 7.2) after 50 Gy and 4.3% (95% CI, 3.2 to 5.9) after 40 Gy. The HR for 40 vs 50 Gy was 0.77 (95% CI, 0.51 to 1.16).\u003C\/p\u003E\u003Cp id=\u0022p-5\u0022\u003ETrial A results showed similar rates of moderate\/marked adverse effects on conserved breast tissue with 41.6 versus 50 Gy (HR, 0.94; 95% CI, 0.79 to 1.11) and suggested lower rates with 39 versus 50 Gy (HR, 0.80; 95% CI, 0.67 to 0.96). In Trial B the rates were lower with 40 versus 50 Gy (HR, 0.77; 95% CI, 0.66 to 0.89).\u003C\/p\u003E\u003Cp id=\u0022p-6\u0022\u003EThe UK START 10-year results indicate that patients can be safely and effectively treated with a lower total dose with fewer fractions than the historical standard of 50 Gy per 25 fractions. No detrimental effects of hypofractionation were identified in patient subgroups, including age \u0026lt;50 or \u0026gt;50 years, type of primary surgery, axillary node status, tumor grade, whether a tumor-bed boost was given, and treatment with adjuvant chemotherapy. These results support the use of 40 Gy in 15 fractions as the UK standard for patients with early invasive breast cancer after breast-conserving surgery or mastectomy, as recommended in the \u003Cem\u003ENICE Clinical Guidelines, No. 80\u003C\/em\u003E [National Institute for Health and Clinical Excellence 2009] and supported by the advice given in the American Society for Radiation Oncology guidelines for fractionation in whole-breast irradiation (for patients not receiving a tumor-bed boost) [Smith BD et al. \u003Cem\u003EInt J Radiat Oncol Biol Phys\u003C\/em\u003E 2010].\u003C\/p\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2013 MD Conference Express\u00ae\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/12\/20\/9.1.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzo4e1\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}