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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/cdn\/css\/http\/css_Xg7z6oCTVgud_Q0huYz9x9iiD5H_2YPSJ5z2ZViSWdY.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003EIdiopathic pulmonary fibrosis (IPF) is a distinctive form of chronic interstitial lung disease occurring primarily in older adults, more often male [Raghu G et al. \u003Cem\u003EAm J Respir Crit Care Med\u003C\/em\u003E 2011]. The estimated prevalence of IPF is 14 to 43 per 100,000 and an estimated incidence is 7 to 16 per 100,000, depending on how it is defined [Raghu G et al. \u003Cem\u003EAm J Respir Crit Care Med\u003C\/em\u003E 2006]. Prognosis can be predicted by the radiographic extent of the disease, amount of fibrosis, presence of pulmonary hypertension, and comorbidities (emphysema, lung cancer, and coronary artery disease).\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003ECancer\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ECoronary Artery Disease\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EThromboembolic Disease Lower Respiratory Infections\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EPneumonia\u003C\/li\u003E\u003C\/ul\u003E\u003Cul class=\u0022kwd-group clinical-trial\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003EOncology\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EPulmonary \u0026amp; Respiratory Medicine\u003C\/li\u003E\u003C\/ul\u003E\u003Cp id=\u0022p-2\u0022\u003EGregory Tino, MD, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA, defined idiopathic pulmonary fibrosis (IPF) as a distinctive form of chronic interstitial lung disease occurring primarily in older adults, more often male [Raghu G et al. \u003Cem\u003EAm J Respir Crit Care Med\u003C\/em\u003E 2011]. The estimated prevalence of IPF is 14 to 43 per 100,000 and an estimated incidence is 7 to 16 per 100,000, depending on how it is defined [Raghu G et al. \u003Cem\u003EAm J Respir Crit Care Med\u003C\/em\u003E 2006]. IPF is often associated with smoking, environmental factors, viral factors, and chronic aspiration associated with gastroesophageal reflux disease (GERD), although its etiology is not well understood. Mortality is high, increasing, and most often due to pulmonary fibrosis, cardiovascular disease, lung cancer, or pneumonia (\u003Ca id=\u0022xref-fig-1-1\u0022 class=\u0022xref-fig\u0022 href=\u0022#F1\u0022\u003EFigure 1\u003C\/a\u003E). Prognosis can be predicted by the radiographic extent of the disease, amount of fibrosis, presence of pulmonary hypertension, and comorbidities (emphysema, lung cancer, and coronary artery disease [CAD]). The median time to death after diagnoses is 3.2 years [Ley B et al. \u003Cem\u003EAnn Intern Med\u003C\/em\u003E 2012], based on the GAP (Gender, Age and Physiology) staging system, a simple scoring model that uses commonly measured clinical and physiologic variables to predict mortality in patients with IPF.\u003C\/p\u003E\u003Cdiv id=\u0022F1\u0022 class=\u0022fig pos-float  odd\u0022\u003E\u003Cdiv class=\u0022highwire-figure\u0022\u003E\u003Cdiv class=\u0022fig-inline-img-wrapper\u0022\u003E\u003Cdiv class=\u0022fig-inline-img\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/13\/4\/30\/F1.large.jpg?width=800\u0026amp;height=600\u0026amp;carousel=1\u0022 title=\u0022IPF Epidemiology: Mortality Rates\u0022 class=\u0022fragment-images colorbox-load\u0022 rel=\u0022gallery-fragment-images-1208892110\u0022 data-figure-caption=\u0022IPF Epidemiology: Mortality Rates\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003E\u003Cimg class=\u0022fragment-image\u0022 alt=\u0022Figure 1.\u0022 src=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/13\/4\/30\/F1.medium.gif\u0022\/\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cul class=\u0022highwire-figure-links inline\u0022\u003E\u003Cli class=\u00220 first\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/13\/4\/30\/F1.large.jpg?download=true\u0022 class=\u0022highwire-figure-link highwire-figure-link-download\u0022 title=\u0022Download Figure 1.\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload figure\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00221\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/13\/4\/30\/F1.large.jpg\u0022 class=\u0022highwire-figure-link highwire-figure-link-newtab\u0022 target=\u0022_blank\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EOpen in new tab\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00222 last\u0022\u003E\u003Ca href=\u0022\/highwire\/powerpoint\/13121\u0022 class=\u0022highwire-figure-link highwire-figure-link-ppt\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload powerpoint\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003Cdiv class=\u0022fig-caption attrib\u0022\u003E\u003Cspan class=\u0022fig-label\u0022\u003EFigure 1.\u003C\/span\u003E \n            \u003Cp id=\u0022p-3\u0022 class=\u0022first-child\u0022\u003EIPF Epidemiology: Mortality Rates\u003C\/p\u003E\n         \u003Cq class=\u0022attrib\u0022 id=\u0022attrib-1\u0022\u003EReprinted with permission of the American Thoracic Society. Olson AL et al. Mortality from Pulmonary Fibrosis Increased in the United States from 1992 to 2003. \u003Cem\u003EAm J Respir Crit Care Med\u003C\/em\u003E 2006;176:277\u2013284. Official journal of the American Thoracic Society.\u003C\/q\u003E\u003Cdiv class=\u0022sb-div caption-clear\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cp id=\u0022p-4\u0022\u003EAcute exacerbations of IPF are common and frequently fatal, but not well understood. Harold R. Collard, MD, University of California, San Francisco, San Francisco, California, USA, reported that acute exacerbations of IPF represent a distinct entity defined as acute, clinically significant deteriorations of unidentifiable cause in patients with underlying IPF. Proposed diagnostic criteria include subjective worsening over \u226430 days, new bilateral radiographic opacities, the absence of microbiological evidence of infection, and exclusion of other causes of acute worsening [Collard HR et al. \u003Cem\u003EAm J Respir Crit Care Med\u003C\/em\u003E 2007]. Acute exacerbation is a significant predictor of poor survival, and appears to be more common in patients with low forced vital capacity and diffusing capacity of the lung for carbon monoxide [Song JW et al. \u003Cem\u003EEur Respir J\u003C\/em\u003E 2011].\u003C\/p\u003E\u003Cp id=\u0022p-5\u0022\u003EPotential triggers of acute exacerbation are viral infection, surgical procedures, microaspiration, and ambient pollution. Preventive measures, including vaccination, avoidance of unnecessary surgery and pollutant exposures, and evaluation and management of GERD, may have a role. Treatment is largely supportive but most patients with acute exacerbation will be treated with antibiotics and corticosteroids [Collard HC et al. \u003Cem\u003EResp Med\u003C\/em\u003E 2007]. There is a \u0026gt;50% mortality at 90 days in most cohorts of patients post-acute exacerbation with a median survival of 2.2 months [Song JW et al. \u003Cem\u003EEur Respir J\u003C\/em\u003E 2011].\u003C\/p\u003E\u003Cp id=\u0022p-6\u0022\u003ECAD has a high prevalence in patients with IPF and has a significant impact on mortality (\u003Ca id=\u0022xref-fig-2-1\u0022 class=\u0022xref-fig\u0022 href=\u0022#F2\u0022\u003EFigure 2\u003C\/a\u003E). In a recent study, patients with IPF were more significantly likely to also have CAD compared with chronic obstructive pulmonary disease (COPD; 65.8% vs 46.1%; p\u0026lt;0.028). Unsuspected significant CAD was found in 18% of IPF patients versus 10.9% of those with COPD (p\u0026lt;0.004) [Nathan SD et al. \u003Cem\u003ERespir Med\u003C\/em\u003E 2010]. In his presentation Steven D. Nathan, MD, George Mason University, Virginia Commonwealth University, Falls Church, Virginia, USA, speculated that IPF might promote atherosclerosis through either cytokine cross talk or plaque instability leading to hypoxia. Although not significant, IPF status appeared predictive of the presence of CAD (adjusted OR, 1.67; 95% CI, 0.59 to 4.78) [Nathan SD et al. \u003Cem\u003ERespir Med\u003C\/em\u003E 2010] as well as for the occurrence of first-time coronary syndromes [Hubbard RB et al. \u003Cem\u003EAm J Respir Crit Care Med\u003C\/em\u003E 2008].\u003C\/p\u003E\u003Cp id=\u0022p-7\u0022\u003EDr. Nathan stated that coronary calcification, assessed by routine CT of the chest, is a good technique for predicting underlying significant CAD in patients with IPF. The sensitivity of moderate to severe calcification was 81%, while the specificity was 85%, with an associated OR of 25.2 (4.64 to 166, p \u0026lt;0.005) with excellent radiologist and pulmonologist agreement in the grading of the coronary calcification [Nathan SD et al. \u003Cem\u003ERespirology\u003C\/em\u003E 2011; Weir N et al. \u003Cem\u003EAm J Respir Crit Care Med\u003C\/em\u003E 2010].\u003C\/p\u003E\u003Cdiv id=\u0022F2\u0022 class=\u0022fig pos-float  odd\u0022\u003E\u003Cdiv class=\u0022highwire-figure\u0022\u003E\u003Cdiv class=\u0022fig-inline-img-wrapper\u0022\u003E\u003Cdiv class=\u0022fig-inline-img\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/13\/4\/30\/F2.large.jpg?width=800\u0026amp;height=600\u0026amp;carousel=1\u0022 title=\u0022Influence of CAD on IPF Mortality\u0022 class=\u0022fragment-images colorbox-load\u0022 rel=\u0022gallery-fragment-images-1208892110\u0022 data-figure-caption=\u0022Influence of CAD on IPF Mortality\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003E\u003Cimg class=\u0022fragment-image\u0022 alt=\u0022Figure 2.\u0022 src=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/13\/4\/30\/F2.medium.gif\u0022\/\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cul class=\u0022highwire-figure-links inline\u0022\u003E\u003Cli class=\u00220 first\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/13\/4\/30\/F2.large.jpg?download=true\u0022 class=\u0022highwire-figure-link highwire-figure-link-download\u0022 title=\u0022Download Figure 2.\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload figure\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00221\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/13\/4\/30\/F2.large.jpg\u0022 class=\u0022highwire-figure-link highwire-figure-link-newtab\u0022 target=\u0022_blank\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EOpen in new tab\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00222 last\u0022\u003E\u003Ca href=\u0022\/highwire\/powerpoint\/13124\u0022 class=\u0022highwire-figure-link highwire-figure-link-ppt\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload powerpoint\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003Cdiv class=\u0022fig-caption attrib\u0022\u003E\u003Cspan class=\u0022fig-label\u0022\u003EFigure 2.\u003C\/span\u003E \n            \u003Cp id=\u0022p-8\u0022 class=\u0022first-child\u0022\u003EInfluence of CAD on IPF Mortality\u003C\/p\u003E\n         \u003Cq class=\u0022attrib\u0022 id=\u0022attrib-2\u0022\u003EReproduced from Nathan SD et al. Prevalence and impact of coronary artery disease in idiopathic pulmonary fibrosis. \u003Cem\u003ERespir Med\u003C\/em\u003E 2010;104(7):1035\u20131041.\u003C\/q\u003E\u003Cdiv class=\u0022sb-div caption-clear\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cp id=\u0022p-9\u0022\u003EMary Elizabeth Kreider, MD, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA, discussed the concomitance of IPF and lung cancer, the latter, of which appears elevated in IPF patients. The frequency of lung cancer in patients with IPF and varies widely by study type and country with prevalence rates of 3% to 48% being reported compared with a non-IPF population. Among more recent studies the lung cancer prevalence rate is in the 5% to 10% range. Risk factors may include male gender, increasing age, and smoking history. Cancer cells are more likely to be peripheral and in lower lobes but not all are near fibrotic areas. Dr. Kreider suggested three possibilities for the link between lung cancer and IPF: IPF causes lung cancer, lung cancer causes IPF, or lung cancer and IPF occur independently but share a common pathogenic mechanism. The impact of the presence of cancer in IPF patients on survival is not clear but survival from time of dual diagnosis is likely poor. Therapy is complicated by high rates of acute exacerbation and difficulty in tolerating interventions.\u003C\/p\u003E\u003Cp id=\u0022p-10\u0022\u003EWhen a clot from a venous thromboembolism (VTE) comes in contact with IPF, there is an increased risk of worse outcome compared with either condition alone. Amy L. Olson, MD, MSPH, University of Colorado, Denver, Colorado, USA, addressed the question of whether the coagulation pathway is activated by IPF or VTE triggers IPF.\u003C\/p\u003E\u003Cp id=\u0022p-11\u0022\u003EAlthough not found in the normal lung, tissue factor (TF) and fibrin have been found in the pneumocytes of IPF patients [Imokawa S et al. \u003Cem\u003EAm J Respir Crit Care Med\u003C\/em\u003E 1997]. In addition, TF levels are significantly higher in advanced versus nonadvanced cases, indicating that excessive procoagulant activity in the alveolar space may play a relevant role in the pathogenesis of IPF [Fuji M et al. \u003Cem\u003EThromb Res\u003C\/em\u003E 2000]. If this hypothesis is true, IPF patients are at increased risk of vascular disease compared with the general population. This effect is most marked for acute coronary syndrome and deep-vein thrombosis (DVT), which is diagnosed at a rate of 5.9\/1000 person years in patients with IPF versus 2.1\/1000 person years in the general population [Hubbard RB et al. \u003Cem\u003EAm J Respir Crit Care Med\u003C\/em\u003E 2008]. Time from a VTE event to a diagnosis of IPF is \u22120.4 years. A diagnosis of IPF is just as likely to follow a diagnosis of VTE as to precede it (\u003Ca id=\u0022xref-fig-3-1\u0022 class=\u0022xref-fig\u0022 href=\u0022#F3\u0022\u003EFigure 3\u003C\/a\u003E) [Sode BF et al. \u003Cem\u003EAm J Respir Crit Care Med\u003C\/em\u003E 2010].\u003C\/p\u003E\u003Cdiv id=\u0022F3\u0022 class=\u0022fig pos-float  odd\u0022\u003E\u003Cdiv class=\u0022highwire-figure\u0022\u003E\u003Cdiv class=\u0022fig-inline-img-wrapper\u0022\u003E\u003Cdiv class=\u0022fig-inline-img\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/13\/4\/30\/F3.large.jpg?width=800\u0026amp;height=600\u0026amp;carousel=1\u0022 title=\u0022Pulmonary Fibrois and VTE\u0022 class=\u0022fragment-images colorbox-load\u0022 rel=\u0022gallery-fragment-images-1208892110\u0022 data-figure-caption=\u0022Pulmonary Fibrois and VTE\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003E\u003Cimg class=\u0022fragment-image\u0022 alt=\u0022Figure 3.\u0022 src=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/13\/4\/30\/F3.medium.gif\u0022\/\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cul class=\u0022highwire-figure-links inline\u0022\u003E\u003Cli class=\u00220 first\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/13\/4\/30\/F3.large.jpg?download=true\u0022 class=\u0022highwire-figure-link highwire-figure-link-download\u0022 title=\u0022Download Figure 3.\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload figure\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00221\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/13\/4\/30\/F3.large.jpg\u0022 class=\u0022highwire-figure-link highwire-figure-link-newtab\u0022 target=\u0022_blank\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EOpen in new tab\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00222 last\u0022\u003E\u003Ca href=\u0022\/highwire\/powerpoint\/13125\u0022 class=\u0022highwire-figure-link highwire-figure-link-ppt\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload powerpoint\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003Cdiv class=\u0022fig-caption attrib\u0022\u003E\u003Cspan class=\u0022fig-label\u0022\u003EFigure 3.\u003C\/span\u003E \n            \u003Cp id=\u0022p-12\u0022 class=\u0022first-child\u0022\u003EPulmonary Fibrois and VTE\u003C\/p\u003E\n         \u003Cq class=\u0022attrib\u0022 id=\u0022attrib-3\u0022\u003EReprinted with permission of the American Thoracic Society. Sode BF et al. Venous Thromboembolism and Risk of Idiopathic Interstitial Pneumonia: A Nationwide Study. \u003Cem\u003EAm J Respir Crit Care Med.\u003C\/em\u003E 2010;181:1085\u20131092. Official journal of the American Thoracic Society.\u003C\/q\u003E\u003Cdiv class=\u0022sb-div caption-clear\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cp id=\u0022p-13\u0022\u003EThe presence of VTE can result in a greater risk of pulmonary fibrosis, COPD, and lung cancer, the combination of which leads to earlier deaths in both men (72.0 vs 74.4 years) and women (74.3 vs 77.4 years; p\u0026lt;0.0001 for both) [Sprunger DB et al. \u003Cem\u003EEur Respir J\u003C\/em\u003E 2012].\u003C\/p\u003E\u003Cp id=\u0022p-14\u0022\u003EPulmonary hypertension (PH) is hemodynamic and pathophysiological condition characterized by the pulmonary arterial pressure \u226525 mm Hg [Galie N et al. \u003Cem\u003EEur Respir J\u003C\/em\u003E 2009]. Precapillary PH is common in patients with severe IPF and is associated with increased mortality and a worse clinical course. MJC Humbert, MD, PhD, H\u00f4pital Antoine B\u00e9cl\u00e8re, Universit\u00e9 Paris-Sud, Clamart, France, commented that PH usually is of mild-to-moderate severity (mPAP 25 to 35 mm Hg), with slow progression and preserved right ventricular function. Severe PH (mPAP \u0026gt;35 mm Hg) may be found in a minority of patients, with some similarities with idiopathic PAH (in this subgroup. Therapies used in PH are generally discouraged (poor efficacy, possible worsening of gas exchange); however, long-term oxygen therapy is the most often therapy of choice if one is used. More randomized controlled trials are needed to test newer treatments.\u003C\/p\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2013 MD Conference Express\u00ae\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/13\/4\/30.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_figures.js?nzny02\u0022\u003E\u003C\/script\u003E\n\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzny02\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}