RT Journal Article
SR Electronic
A1 Vinall, Phil
T1 Prevention and Early Treatment of Acute Lung Injury
JF MD Conference Express
YR 2013
FD SAGE Publications
VO 13
IS 4
SP 6
OP 7
DO 10.1177/155989771304001
UL http://mdc.sagepub.com/content/13/4/6.abstract
AB The absence of Phase 3 trials showing a mortality benefit from pharmacological treatment of acute lung injury (ALI) has led to a shift toward identifying patients who are at risk for lung injury and employing risk modification and treatment to prevent progression to respiratory failure or the need for mechanical ventilation. Such an approach includes the use of novel pharmaceutical agents in addition to those previously used unsuccessfully to treat established acute respiratory distress syndrome. This strategy also includes identifying and treating at-risk patients in the emergency department or even perioperatively and is not limited to targeting patients in the intensive care unit.