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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/advagg_css\/css__ce2QY63WIanKyr8eSq7eavr1XQRRmFD6ZSmwpyJi8lM__zXwFqpqmxrZOXXcd_TpBQpjuELbmIP9wBR5UuTDWAO4__YJWWMMdfCJuAFm5cUEp88OsodhO3ZA-2lzRfoBsSlk4.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003EHypertensive patients aged =75 years have a lower risk of stroke when they take calcium channel blockers (CCBs) along with olmesartan than when they take diuretics with olmesartan, according to the results of the Combination of Olmesartan and CCB or Low Dose Diuretics in High Risk Elderly Hypertensive Patients Study [COLM; \u003Ca class=\u0022external-ref external-ref-type-clintrialgov\u0022 href=\u0022\/lookup\/external-ref?link_type=CLINTRIALGOV\u0026amp;access_num=NCT00454662\u0026amp;atom=%2Fspmdc%2F13%2F9%2F8.1.atom\u0022\u003ENCT00454662\u003C\/a\u003E]. Furthermore, the incidence of serious adverse events and discontinuation from the trial due to drug-related serious adverse events were also lower in elderly hypertensive patients receiving CCBs.\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003ECardiology Clinical Trials\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EHypertensive Disease\u003C\/li\u003E\u003C\/ul\u003E\u003Cul class=\u0022kwd-group clinical-trial\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003ECardiology Clinical Trials\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ECardiology \u0026amp; Cardiovascular Medicine\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EHypertensive Disease\u003C\/li\u003E\u003C\/ul\u003E\u003Cp id=\u0022p-2\u0022\u003EHypertensive patients aged \u226575 years have a lower risk of stroke when they take calcium channel blockers (CCBs) along with olmesartan than when they take diuretics with olmesartan, according to the results of the Combination of Olmesartan and CCB or Low Dose Diuretics in High Risk Elderly Hypertensive Patients Study [COLM; \u003Ca class=\u0022external-ref external-ref-type-clintrialgov\u0022 href=\u0022\/lookup\/external-ref?link_type=CLINTRIALGOV\u0026amp;access_num=NCT00454662\u0026amp;atom=%2Fspmdc%2F13%2F9%2F8.1.atom\u0022\u003ENCT00454662\u003C\/a\u003E]. Furthermore, the incidence of serious adverse events and discontinuation from the trial due to drug-related serious adverse events were also lower in elderly hypertensive patients receiving CCBs. The findings of this study were presented by Toshio Ogihara, MD, PhD, Morinomiya University of Medical Sciences, Osaka, Japan.\u003C\/p\u003E\u003Cp id=\u0022p-3\u0022\u003ECOLM is the first study to compare the effects of CCBs with those of diuretics in preventing cardiovascular disease when used in conjunction with olmesartan [Ogihara T et al. \u003Cem\u003EHypertens Res\u003C\/em\u003E 2009]. It was a multicenter, randomized, open-label, blinded-endpoint trial, conducted at 707 centers in Japan. High-risk elderly hypertensive Japanese patients (n=5141) aged 65 to 84 years were randomized to either CCBs plus olmesartan (n=2568) or low-dose diuretics plus olmesartan (n=2573). Of those in the CCB group, 38.1% were on CCBs at the start of enrollment versus with 35.8% in the diuretic group. The target blood pressure (BP) was \u0026lt;140\/90 mm Hg.\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003EPatients were followed-up for a median of 3.3 years. In both groups, BP decreased similarly, from 158\/87 mm Hg at baseline to 132\/73 mm Hg at the study end. The primary composite endpoint of fatal and nonfatal cardiovascular events was similar between the CCB and diuretic groups during the study (4.5% vs 5.3%; HR, 0.83; 95% CI, 0.65 to 1.07; p=0.16). None of the components of this endpoint were significantly different between the two groups.\u003C\/p\u003E\u003Cp id=\u0022p-5\u0022\u003EIn the subgroup of patients aged \u226575 years, the risk of the primary composite endpoint was significantly lower in the CCB group (5.2%) versus the diuretic group (7.2%; HR, 0.70; p=0.04). The risk of stroke was also significantly lower in the CCB group (2.4% vs 3.8%; HR, 0.63; p=0.05). However, there was no significant difference in the risk of cardiac events between the CCB and diuretic groups (1.9% vs 2.2%; HR, 0.83; p=0.68).\u003C\/p\u003E\u003Cp id=\u0022p-6\u0022\u003EOverall, and regardless of the age subgroup (\u0026lt;75 or \u226575 years), 25.3% of CCB versus 29.1% of diuretic group patients experienced an adverse event (p=0.002). 8.2% of patients in the CCB group experienced serious adverse events compared with 9.8% in the diuretic group (p=0.046). The rate of discontinuation due to drug-related serious adverse events was also significantly lower in the CCB group (0.2% vs 0.6%; p\u0026lt;0.026).\u003C\/p\u003E\u003Cp id=\u0022p-7\u0022\u003ECOLM findings show that while CCBs and diuretics were equally effective at controlling BP in elderly patients with hypertension when given in combination with olmesartan, CCBs were more effective in preventing stroke in patients aged \u226575 years and were associated with a decreased risk of adverse events in all patients.\u003C\/p\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2013 MD Conference Express\u00ae\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/13\/9\/8.1.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nznue1\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}