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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/cdn\/css\/http\/css_Xg7z6oCTVgud_Q0huYz9x9iiD5H_2YPSJ5z2ZViSWdY.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003EThere is often a long time interval between the onset of stroke and treatment. Current transfer systems for getting patients to hospital or catheterization laboratories in order to undergo treatment are poorly developed. Additionally, current therapies are limited. This article discusses new data which may change the management of patients with acute stroke.\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003EInterventional Techniques \u0026amp; Devices\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ECerebrovascular Disease\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EInterventional Radiology\u003C\/li\u003E\u003C\/ul\u003E\u003Cul class=\u0022kwd-group clinical-trial\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003EInterventional Techniques \u0026amp; Devices\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ECardiology \u0026amp; Cardiovascular Medicine\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ECerebrovascular Disease\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EInterventional Radiology\u003C\/li\u003E\u003C\/ul\u003E\u003Cp id=\u0022p-2\u0022\u003EHorst Sievert, MD, CardioVascular Center Frankfurt, Frankfurt, Germany, discussed new data which may change the management of patients with acute stroke. He noted that there is often a long time interval between the onset of stroke and treatment. In addition, current transfer systems for getting patients to hospital or catheterization laboratories in order to undergo treatment are poorly developed. Finally, current therapies are limited.\u003C\/p\u003E\u003Cp id=\u0022p-3\u0022\u003EThe amount time in which the brain is without blood flow impacts the severity of the stroke and potential for recovery. There is often a considerable delay from the time in which patients first develop symptoms to the time in which they seek treatment. Efforts must be made to educate patients about the early signs of transient ischemic attack (TIA)\/stroke and the need to quickly seek medical care when these symptoms occur. The time to treatment may also be improved by using ambulances specifically designed for transporting stroke patients. It may also be possible to reduce the amount of time needed to make the diagnosis of a stroke by utilizing mobile computed tomography (CT) scanners or bypassing the Emergency Department and taking patients directly to imaging. Providers could then take a history can be taken, perform lab tests, and ready the patient for thrombolysis while the patient is preparing to undergo imaging.\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003EExpediting the treatment of patients with thrombolysis is important since data from a pooled analysis of early administration of recombinant tissue plasminogen activator (rtPA) after ischemic stroke showed benefit out to 4.5 hours after stroke onset. After 4.5 hours, the risk of thrombolysis may outweigh its potential benefits (\u003Ca id=\u0022xref-fig-1-1\u0022 class=\u0022xref-fig\u0022 href=\u0022#F1\u0022\u003EFigure 1\u003C\/a\u003E) [Lees KR et al. \u003Cem\u003ELancet\u003C\/em\u003E 2010].\u003C\/p\u003E\u003Cdiv id=\u0022F1\u0022 class=\u0022fig pos-float  odd\u0022\u003E\u003Cdiv class=\u0022highwire-figure\u0022\u003E\u003Cdiv class=\u0022fig-inline-img-wrapper\u0022\u003E\u003Cdiv class=\u0022fig-inline-img\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/13\/7\/27\/F1.large.jpg?width=800\u0026amp;height=600\u0026amp;carousel=1\u0022 title=\u0022Pooled Analysis rtPA for Acute Ischemic Stroke: Favorable Outcome (mRS 0\u0026#x2013;1) Versus Time\u0022 class=\u0022fragment-images colorbox-load\u0022 rel=\u0022gallery-fragment-images-1047693825\u0022 data-figure-caption=\u0022Pooled Analysis rtPA for Acute Ischemic Stroke: Favorable Outcome (mRS 0\u0026#x2013;1) Versus Time\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003E\u003Cimg class=\u0022fragment-image\u0022 alt=\u0022Figure 1.\u0022 src=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/13\/7\/27\/F1.medium.gif\u0022\/\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cul class=\u0022highwire-figure-links inline\u0022\u003E\u003Cli class=\u00220 first\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/13\/7\/27\/F1.large.jpg?download=true\u0022 class=\u0022highwire-figure-link highwire-figure-link-download\u0022 title=\u0022Download Figure 1.\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload figure\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00221\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/13\/7\/27\/F1.large.jpg\u0022 class=\u0022highwire-figure-link highwire-figure-link-newtab\u0022 target=\u0022_blank\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EOpen in new tab\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00222 last\u0022\u003E\u003Ca href=\u0022\/highwire\/powerpoint\/13358\u0022 class=\u0022highwire-figure-link highwire-figure-link-ppt\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload powerpoint\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003Cdiv class=\u0022fig-caption attrib\u0022\u003E\u003Cspan class=\u0022fig-label\u0022\u003EFigure 1.\u003C\/span\u003E \n            \u003Cp id=\u0022p-5\u0022 class=\u0022first-child\u0022\u003EPooled Analysis rtPA for Acute Ischemic Stroke: Favorable Outcome (mRS 0\u20131) Versus Time\u003C\/p\u003E\n         \u003Cq class=\u0022attrib\u0022 id=\u0022attrib-1\u0022\u003EReproduced from Lees KR et al. Time to treatment with intravenous alteplase and outcome in stroke: an updated pooled analysis of ECASS, ATLANTIS, NINDS, and EPITHET trials. \u003Cem\u003ELancet\u003C\/em\u003E 2010;375(9727):1695\u20131703. With permission from Elsevier.\u003C\/q\u003E\u003Cdiv class=\u0022sb-div caption-clear\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cp id=\u0022p-6\u0022\u003EThrombolysis improves outcomes in patients with acute ischemic stroke; however, the success of thrombolysis for the recanalization of large clots is poor (\u223c10% success) and reocclusion occurs in \u223c20% of patients who initially have successful reperfusion. The use of angiography allows for better localization of the occlusion and allows for direct administration of thrombolytics to thrombus. In addition, mechanical thrombectomy devices can be used to obtain immediate reperfusion.\u003C\/p\u003E\u003Cp id=\u0022p-7\u0022\u003EAlthough thrombolysis is still the gold standard therapy for acute stroke, more centers are developing clinical pathways based on severity, duration of symptoms, and the use of catheter intervention. Data from the PROACT-II study [Furlan A et al. \u003Cem\u003EJAMA\u003C\/em\u003E 1999], IMS II trial [IMS Trial Investigators. \u003Cem\u003EStroke\u003C\/em\u003E 2007], and RECANLISE registry [Sen S et al. \u003Cem\u003ENeurocrit Care\u003C\/em\u003E 2009], support the use of a catheter invention approach; however, recent data show no benefit from mechanical lysis compared with IV tPA (IMS III [Broderick JP et al. \u003Cem\u003EN Engl J Med\u003C\/em\u003E 2013], SYNTHESIS [Ciccone A et al. \u003Cem\u003EN Engl J Med\u003C\/em\u003E 2013], and MR Rescue [Kidwell CS et al. \u003Cem\u003EN Engl J Med\u003C\/em\u003E 2013]). As a result, the optimal treatment for patients with ischemic stroke remains undefined.\u003C\/p\u003E\u003Cp id=\u0022p-8\u0022\u003EProf. Sievert proposed an algorithm to guide treatment selection based on time since symptom onset (\u003Ca id=\u0022xref-table-wrap-1-1\u0022 class=\u0022xref-table\u0022 href=\u0022#T1\u0022\u003ETable 1\u003C\/a\u003E).\u003C\/p\u003E\u003Cdiv id=\u0022T1\u0022 class=\u0022table pos-float\u0022\u003E\u003Cdiv class=\u0022table-inline\u0022\u003E\u003Cdiv class=\u0022callout\u0022\u003E\u003Cspan\u003EView this table:\u003C\/span\u003E\u003Cul class=\u0022callout-links\u0022\u003E\u003Cli class=\u00220 first\u0022\u003E\u003Ca href=\u0022\/\u0022 class=\u0022table-expand-inline\u0022 data-table-url=\u0022\/highwire\/markup\/13360\/expansion?postprocessors=highwire_figures%2Chighwire_math%2Chighwire_inline_linked_media%2Chighwire_embed\u0026amp;table-expand-inline=1\u0022 html=\u00221\u0022 fragment=\u0022#\u0022 external=\u00221\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView inline\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00221\u0022\u003E\u003Ca href=\u0022\/highwire\/markup\/13360\/expansion?width=1000\u0026amp;height=500\u0026amp;iframe=true\u0026amp;postprocessors=highwire_figures%2Chighwire_math%2Chighwire_inline_linked_media\u0022 class=\u0022colorbox colorbox-load table-expand-popup\u0022 rel=\u0022gallery-fragment-tables\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView popup\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00222 last\u0022\u003E\u003Ca href=\u0022\/highwire\/powerpoint\/13360\u0022 class=\u0022highwire-figure-link highwire-figure-link-ppt\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload powerpoint\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cdiv class=\u0022table-caption\u0022\u003E\u003Cspan class=\u0022table-label\u0022\u003ETable 1.\u003C\/span\u003E \n            \u003Cp id=\u0022p-9\u0022 class=\u0022first-child\u0022\u003ETreatment Algorithm\u003C\/p\u003E\n         \u003Cdiv class=\u0022sb-div caption-clear\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cp id=\u0022p-11\u0022\u003EUnder multisociety consensus quality improvement guidelines [Sacks D et al. \u003Cem\u003ECatheter Cardiovasc Interv\u003C\/em\u003E 2013], patients with the following characteristic benefit the most from mechanical recanalization:\u003C\/p\u003E\u003Cp\u003E\n         \u003C\/p\u003E\u003Cul class=\u0022list-simple \u0022 id=\u0022list-1\u0022\u003E\u003Cli id=\u0022list-item-1\u0022\u003E\n               \u003Cp id=\u0022p-13\u0022\u003E\u25aa Patients in whom IV tPA is contraindicated or in whom IV tPA has failed or is likely to fail\u003C\/p\u003E\n            \u003C\/li\u003E\u003Cli id=\u0022list-item-2\u0022\u003E\n               \u003Cp id=\u0022p-14\u0022\u003E\u25aa Patients with large vessel occlusion\u003C\/p\u003E\n            \u003C\/li\u003E\u003Cli id=\u0022list-item-3\u0022\u003E\n               \u003Cp id=\u0022p-15\u0022\u003E\u25aa Very symptomatic patients\u003C\/p\u003E\n            \u003C\/li\u003E\u003Cli id=\u0022list-item-4\u0022\u003E\n               \u003Cp id=\u0022p-16\u0022\u003E\u25aa Patients with a stroke time window out to 8 hours\u003C\/p\u003E\n            \u003C\/li\u003E\u003Cli id=\u0022list-item-5\u0022\u003E\n               \u003Cp id=\u0022p-17\u0022\u003E\u25aa Patients with a proximal artery occlusion\u003C\/p\u003E\n            \u003C\/li\u003E\u003C\/ul\u003E\u003Cp\u003E\n      \u003C\/p\u003E\u003Cp id=\u0022p-18\u0022\u003E\u201cThere is only one effective treatment for ischemic stroke,\u201d said Prof. Sievert, \u201cto get the vessel open.\u201d\u003C\/p\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2013 MD Conference 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