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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/advagg_css\/css__ce2QY63WIanKyr8eSq7eavr1XQRRmFD6ZSmwpyJi8lM__zXwFqpqmxrZOXXcd_TpBQpjuELbmIP9wBR5UuTDWAO4__YJWWMMdfCJuAFm5cUEp88OsodhO3ZA-2lzRfoBsSlk4.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003EThe incidence of coronary artery disease has reached epidemic levels in Saudi Arabia [Al-Nozha MM et al. \u003Cem\u003ESaudi Med J\u003C\/em\u003E 2004]. In addition, Saudi Arabia has the highest prevalence of diabetes in the Middle East [Al-Nozha MM et al. \u003Cem\u003ESaudi Med J\u003C\/em\u003E 2004). As a result, the Saudi Coronary Athero-Thrombotic disease study [SAUDICAT] sought to use intravascular ultrasound to define the spectrum of coronary atherothrombotic disease in Saudi nationals with acute coronary syndromes [Lawand S et al. \u003Cem\u003EJ Saudi Heart Assoc\u003C\/em\u003E 2012].\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003EMyocardial Infarction Clinical Trials\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EDiabetes Mellitus\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ECoronary Artery Disease\u003C\/li\u003E\u003C\/ul\u003E\u003Cul class=\u0022kwd-group clinical-trial\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003EMyocardial Infarction\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ECardiology Clinical Trials\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ECardiology \u0026amp; Cardiovascular Medicine\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EDiabetes Mellitus\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ECoronary Artery Disease\u003C\/li\u003E\u003C\/ul\u003E\u003Cp id=\u0022p-2\u0022\u003EThe incidence of coronary artery disease (CAD) has reached epidemic levels in Saudi Arabia. [Al-Nozha MM et al. \u003Cem\u003ESaudi Med J\u003C\/em\u003E 2004]. In addition, Saudi Arabia has the highest prevalence of diabetes (DM) in the Middle East [Al-Nozha MM et al. \u003Cem\u003ESaudi Med J\u003C\/em\u003E 2004). As a result, the Saudi Coronary Athero-Thrombotic disease study [SAUDICAT] sought to use intravascular ultrasound to define the spectrum of coronary atherothrombotic disease in Saudi nationals with acute coronary syndromes (ACS) [Lawand S et al. \u003Cem\u003EJ Saudi Heart Assoc\u003C\/em\u003E 2012]. Samih Lawand, MD, Prince Salman Heart Center, Riyadh, Saudi Arabia, presented the preliminary results of the first 59 consecutive patients enrolled in this study.\u003C\/p\u003E\u003Cp id=\u0022p-3\u0022\u003EThe patients were mostly men (78%), 46% currently smoked and two thirds had DM. The presenting diagnosis was ST-segment elevation myocardial infarction (STEMI) in 25% of patients, non-STEMI (NSTEMI) in 42%, and unstable angina in 32% of patients.\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003EThe rate of NSTEMI was significantly higher in the 39 patients with DM (60%) compared with those without DM (40%; p=0.009). The incidence of hypertension (75% vs 26%; p=0.053) and dyslipidemia (70% vs 30%; p=0.59) was also more prevalent in patients with NSTEMI. STEMI was more common in patients without DM.\u003C\/p\u003E\u003Cp id=\u0022p-5\u0022\u003EDifferences in the coronary anatomy and structure were found between patients with DM, as compared with patients without DM, including significantly smaller vessel diameters, smaller lumen diameters, smaller vessel areas, and smaller plaque areas among patients with DM (\u003Ca id=\u0022xref-table-wrap-1-1\u0022 class=\u0022xref-table\u0022 href=\u0022#T1\u0022\u003ETable 1\u003C\/a\u003E).\u003C\/p\u003E\u003Cdiv id=\u0022T1\u0022 class=\u0022table pos-float\u0022\u003E\u003Cdiv class=\u0022table-inline\u0022\u003E\u003Cdiv class=\u0022callout\u0022\u003E\u003Cspan\u003EView this table:\u003C\/span\u003E\u003Cul class=\u0022callout-links\u0022\u003E\u003Cli class=\u00220 first\u0022\u003E\u003Ca href=\u0022\/\u0022 class=\u0022table-expand-inline\u0022 data-table-url=\u0022\/highwire\/markup\/13346\/expansion?postprocessors=highwire_figures%2Chighwire_math%2Chighwire_inline_linked_media%2Chighwire_embed\u0026amp;table-expand-inline=1\u0022 html=\u00221\u0022 fragment=\u0022#\u0022 external=\u00221\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView inline\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00221\u0022\u003E\u003Ca href=\u0022\/highwire\/markup\/13346\/expansion?width=1000\u0026amp;height=500\u0026amp;iframe=true\u0026amp;postprocessors=highwire_figures%2Chighwire_math%2Chighwire_inline_linked_media\u0022 class=\u0022colorbox colorbox-load table-expand-popup\u0022 rel=\u0022gallery-fragment-tables\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView popup\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00222 last\u0022\u003E\u003Ca href=\u0022\/highwire\/powerpoint\/13346\u0022 class=\u0022highwire-figure-link highwire-figure-link-ppt\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload powerpoint\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cdiv class=\u0022table-caption\u0022\u003E\u003Cspan class=\u0022table-label\u0022\u003ETable 1.\u003C\/span\u003E \n            \u003Cp id=\u0022p-6\u0022 class=\u0022first-child\u0022\u003EIVUS Characterization of Coronary Vessels in Patients With and Without Diabetes\u003C\/p\u003E\n         \u003Cdiv class=\u0022sb-div caption-clear\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cp id=\u0022p-7\u0022\u003EPatients with DM who presented with STEMI were more likely to have significantly smaller vessel diameters, luminal diameters, and plaque areas. In contrast, patients with DM who presented with NSTEMI had significantly larger plaque areas (p=0.0003) and plaque burden (p=0.0033), and a trend for a larger remodeling index (p=0.3345) that was not significantly different compared without DM. In the setting of unstable angina, no significant differences were seen between the patients with and without DM.\u003C\/p\u003E\u003Cp id=\u0022p-8\u0022\u003EPatients with diabetes presenting with STEMI or NSTEMI were more likely to have a greater plaque burden and larger plaque area, which Prof. Lawand hypothesized may be due to advanced atherosclerosis. Although patients with diabetes had smaller coronary vessels overall, he noted that the size of the plaque area and percent volume obstruction was similar to patients without diabetes.\u003C\/p\u003E\u003Cp id=\u0022p-9\u0022\u003EProf. Lawand concluded that this small, retrospective analysis of intravascular ultrasound (IVUS) data highlights the need for improvements in the use of IVUS and provides a framework to better understand the characteristics of coronary atherosclerosis in a Middle Eastern population.\u003C\/p\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2013 MD Conference Express\u00ae\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/13\/7\/12.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nznt3e\u0022\u003E\u003C\/script\u003E\n\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_tables.js?nznt3e\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}