RT Journal Article
SR Electronic
A1 Kuznar, Wayne
T1 Protein Bioengineering Strategies Improve upon Hemophilia Treatments
JF MD Conference Express
YR 2013
FD SAGE Publications
VO 13
IS 13
SP 15
OP 16
DO 10.1177/155989771313008
UL http://mdc.sagepub.com/content/13/13/15.abstract
AB A new era in the treatment of hemophilia has emerged with a new generation of protein therapeutics. This article provides an overview of the future of coagulation factor replacement therapy. Protein engineering has increased the clinical potential and reduced rapid clearance of antihemophilic drugs from the body. Current therapy for hemophilia is safe and effective but immunogenic. Next generation antihemophilic drugs should have enhanced efficacy, greater safety, reduced immunogenicity, and improved delivery.