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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/cdn\/css\/http\/css_Xg7z6oCTVgud_Q0huYz9x9iiD5H_2YPSJ5z2ZViSWdY.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003EThis article addresses the rising problem of hypertension and its complications, especially in black patients. Included topics are strategies for maximizing blood pressure (BP) control and the current BP goals as recommended by 2013 European Society of Hypertension (ESH)-European Society of Cardiology (ESC) and Joint National Committee (JNC) 7 guidelines.\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003EHypertensive Disease\u003C\/li\u003E\u003C\/ul\u003E\u003Cul class=\u0022kwd-group clinical-trial\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003ECardiology \u0026amp; Cardiovascular Medicine\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EHypertensive Disease\u003C\/li\u003E\u003C\/ul\u003E\u003Cp id=\u0022p-2\u0022\u003EArthur Liqui-Lung, MD, Stichting Teaching Hospital, Willemstad, Cura\u00e7ao, Netherlands Antilles, addressed the rising problem of hypertension and its complications, especially in black patients. He discussed strategies for maximizing blood pressure (BP) control and the current BP goals as recommended by 2013 European Society of Hypertension (ESH)\u2013European Society of Cardiology (ESC) and Joint National Committee (JNC) 7 guidelines.\u003C\/p\u003E\u003Cp id=\u0022p-3\u0022\u003EHypertension is already a major global health challenge with the prevalence only expected to increase in the coming decades. Based on a pooled analysis of regional data, an estimated 972 million adults worldwide had hypertension in 2000 with a predicted increase by 60% to 1.56 billion by 2025 [Kearney PM et al. \u003Cem\u003ELancet\u003C\/em\u003E 2005]. To maximize the reduction in the long-term risk of death owing to cardiovascular consequences, prevention and control of hypertension will be critical. Even a 2-mm Hg reduction in systolic BP can lower mortality risk from ischemic heart disease and stroke by 7% and 10%, respectively [Lewington S et al. \u003Cem\u003ELancet\u003C\/em\u003E 2002].\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003ECurrent guidelines indicate a target BP of \u0026lt;140\/90 mm Hg for patients without diabetes mellitus, kidney disease, or cardiovascular disease, with lower targets for those with one or more of these conditions (\u003Ca id=\u0022xref-table-wrap-1-1\u0022 class=\u0022xref-table\u0022 href=\u0022#T1\u0022\u003ETable 1\u003C\/a\u003E). Despite knowledge on lifestyle interventions and availability of effective medications, even countries with enviable healthcare systems report low attainment of current BP targets. A 2004 European study demonstrated that as many as 80% of patients receiving therapy for hypertension fail to reach target BP goals of \u0026lt;140\/90 mm Hg (\u003Ca id=\u0022xref-fig-1-1\u0022 class=\u0022xref-fig\u0022 href=\u0022#F1\u0022\u003EFigure 1\u003C\/a\u003E) [Wolf-Maier K et al. \u003Cem\u003EHypertension\u003C\/em\u003E 2004].\u003C\/p\u003E\u003Cdiv id=\u0022T1\u0022 class=\u0022table pos-float\u0022\u003E\u003Cdiv class=\u0022table-inline\u0022\u003E\u003Cdiv class=\u0022callout\u0022\u003E\u003Cspan\u003EView this table:\u003C\/span\u003E\u003Cul class=\u0022callout-links\u0022\u003E\u003Cli class=\u00220 first\u0022\u003E\u003Ca href=\u0022\/\u0022 class=\u0022table-expand-inline\u0022 data-table-url=\u0022\/highwire\/markup\/13694\/expansion?postprocessors=highwire_figures%2Chighwire_math%2Chighwire_inline_linked_media%2Chighwire_embed\u0026amp;table-expand-inline=1\u0022 html=\u00221\u0022 fragment=\u0022#\u0022 external=\u00221\u0022 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1.\u003C\/span\u003E \n            \u003Cp id=\u0022p-5\u0022 class=\u0022first-child\u0022\u003ECurrent BP Guidelines\u003C\/p\u003E\n         \u003Cdiv class=\u0022sb-div caption-clear\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cdiv id=\u0022F1\u0022 class=\u0022fig pos-float  odd\u0022\u003E\u003Cdiv class=\u0022highwire-figure\u0022\u003E\u003Cdiv class=\u0022fig-inline-img-wrapper\u0022\u003E\u003Cdiv class=\u0022fig-inline-img\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/13\/14\/29\/F1.large.jpg?width=800\u0026amp;height=600\u0026amp;carousel=1\u0022 title=\u0022Failure to Achieve BP Goals in Europe\u0022 class=\u0022fragment-images colorbox-load\u0022 rel=\u0022gallery-fragment-images-1340138469\u0022 data-figure-caption=\u0022Failure to Achieve BP Goals in Europe\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003E\u003Cimg class=\u0022fragment-image\u0022 alt=\u0022Figure 1.\u0022 src=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/13\/14\/29\/F1.medium.gif\u0022\/\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cul class=\u0022highwire-figure-links inline\u0022\u003E\u003Cli class=\u00220 first\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/13\/14\/29\/F1.large.jpg?download=true\u0022 class=\u0022highwire-figure-link highwire-figure-link-download\u0022 title=\u0022Download Figure 1.\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload figure\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00221\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/13\/14\/29\/F1.large.jpg\u0022 class=\u0022highwire-figure-link highwire-figure-link-newtab\u0022 target=\u0022_blank\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EOpen in new tab\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00222 last\u0022\u003E\u003Ca href=\u0022\/highwire\/powerpoint\/13692\u0022 class=\u0022highwire-figure-link highwire-figure-link-ppt\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload powerpoint\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003Cdiv class=\u0022fig-caption attrib\u0022\u003E\u003Cspan class=\u0022fig-label\u0022\u003EFigure 1.\u003C\/span\u003E \n            \u003Cp id=\u0022p-10\u0022 class=\u0022first-child\u0022\u003EFailure to Achieve BP Goals in Europe\u003C\/p\u003E\n         \u003Cq class=\u0022attrib\u0022 id=\u0022attrib-1\u0022\u003EBP=blood pressure.\u003C\/q\u003E\u003Cq class=\u0022attrib\u0022 id=\u0022attrib-2\u0022\u003ESource: Wolf-Maier K et al. \u003Cem\u003EHypertension\u003C\/em\u003E 2004.\u003C\/q\u003E\u003Cdiv class=\u0022sb-div caption-clear\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cp id=\u0022p-11\u0022\u003EDr. Liqui-Lung highlighted that hypertension and its sequelae are more prevalent in black patients, providing an even greater challenge to regions like the Caribbean with a high proportion of patients with African ancestry [Flack JM et al. \u003Cem\u003EHypertension\u003C\/em\u003E 2010]. In addition, there are important differences regarding hypertension in blacks including, a greater role for hypertension in the development of heart failure, different responses to standard therapies, and greater difficulty in achieving current targets. In its 2010 consensus statement, the International Society on Hypertension in Blacks prioritized lifestyle education even in the setting of \u201cnormal\u201d BP, slightly earlier initiation of pharmacologic therapy at 135\/85 mm Hg in comorbidities, and rapidly switching from single to combination drug therapy if BP does not decrease quickly.\u003C\/p\u003E\u003Cp id=\u0022p-12\u0022\u003EMedication compliance and persistence can significantly BP as well as overall medical costs significantly [Sokol MC et al. \u003Cem\u003EMed Care\u003C\/em\u003E 2005]. Realizing these benefits, however, is a considerable challenge in an era of polypharmacy and with adequate hypertension therapy often requiring more than one agent [D\u00fcsing R. \u003Cem\u003EVasc Health Risk Manag\u003C\/em\u003E 2010; Mancia G et al. \u003Cem\u003EBlood Press\u003C\/em\u003E 2009; Chobanian AV et al. \u003Cem\u003EHypertension\u003C\/em\u003E 2007; Milani RV. \u003Cem\u003EAm J Manag Care\u003C\/em\u003E 2005; Materson BJ et al. \u003Cem\u003EN Engl J Med\u003C\/em\u003E 1993; D\u00fcsing R. \u003Cem\u003EVasc Health Risk Manag\u003C\/em\u003E 2010; Mancia G et al. \u003Cem\u003EBlood Press.\u003C\/em\u003E 2009]. One study also showed that when a drug from a second class of BP-lowering agents is combined with a patient\u0027s first antihypertensive drug, BP is reduced 5 times more than if the dose of the first drug was doubled [Wald DS et al. \u003Cem\u003EAm J Med\u003C\/em\u003E 2009].\u003C\/p\u003E\u003Cp id=\u0022p-13\u0022\u003EDr. Liqui-Lung discussed evidence demonstrating that patients receiving combination drug therapy (ie, in a single pill) were significantly (p\u0026lt;0.0001) more likely to adhere to therapy than those receiving free-combination therapy [Gerbino PP, Shoheiber O. \u003Cem\u003EAm J Health Syst Pharm\u003C\/em\u003E 2007]. The ESH\u2013ESC and JNC 7 guidelines recommend initiation of combination drug therapy in all patients with BP \u0026gt;20\/10 mm Hg above goal or in patients with a high risk of CVD (\u003Ca id=\u0022xref-fig-2-1\u0022 class=\u0022xref-fig\u0022 href=\u0022#F2\u0022\u003EFigure 2\u003C\/a\u003E) [Lenfant C et al. \u003Cem\u003EHypertension\u003C\/em\u003E 2003; Mancia G et al. \u003Cem\u003EBlood Press\u003C\/em\u003E 2009].\u003C\/p\u003E\u003Cdiv id=\u0022F2\u0022 class=\u0022fig pos-float  odd\u0022\u003E\u003Cdiv class=\u0022highwire-figure\u0022\u003E\u003Cdiv class=\u0022fig-inline-img-wrapper\u0022\u003E\u003Cdiv class=\u0022fig-inline-img\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/13\/14\/29\/F2.large.jpg?width=800\u0026amp;height=600\u0026amp;carousel=1\u0022 title=\u0022ESH-ESC Guidelines for Combining Antihypertensive Drugs]\u0022 class=\u0022fragment-images colorbox-load\u0022 rel=\u0022gallery-fragment-images-1340138469\u0022 data-figure-caption=\u0022ESH-ESC Guidelines for Combining Antihypertensive Drugs]\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003E\u003Cimg class=\u0022fragment-image\u0022 alt=\u0022Figure 2.\u0022 src=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/13\/14\/29\/F2.medium.gif\u0022\/\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cul class=\u0022highwire-figure-links inline\u0022\u003E\u003Cli class=\u00220 first\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/13\/14\/29\/F2.large.jpg?download=true\u0022 class=\u0022highwire-figure-link highwire-figure-link-download\u0022 title=\u0022Download Figure 2.\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload figure\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00221\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/13\/14\/29\/F2.large.jpg\u0022 class=\u0022highwire-figure-link highwire-figure-link-newtab\u0022 target=\u0022_blank\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EOpen in new tab\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00222 last\u0022\u003E\u003Ca href=\u0022\/highwire\/powerpoint\/13693\u0022 class=\u0022highwire-figure-link highwire-figure-link-ppt\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload powerpoint\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003Cdiv class=\u0022fig-caption attrib\u0022\u003E\u003Cspan class=\u0022fig-label\u0022\u003EFigure 2.\u003C\/span\u003E \n            \u003Cp id=\u0022p-14\u0022 class=\u0022first-child\u0022\u003EESH-ESC Guidelines for Combining Antihypertensive Drugs]\u003C\/p\u003E\n         \u003Cq class=\u0022attrib\u0022 id=\u0022attrib-3\u0022\u003EReproduced from Mancia G et al. 2013 ESH\/ESC Guidelines for the management of arterial hypertension: The Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). \u003Cem\u003EEur Heart J\u003C\/em\u003E 2013;34(28)2159\u20132219. 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