PT  - JOURNAL ARTICLE
AU  - Rizzo, Toni
ED  - van de Werf, Frans
TI  - Dabigatran Inferior to Warfarin in Patients with Mechanical Heart Valves
DP  - 2013 Nov 01
TA  - MD Conference Express
PG  - 10--11
VI  - 13
IP  - 15
4099  - http://mdc.sagepub.com/content/13/15/10.short
4100  - http://mdc.sagepub.com/content/13/15/10.full
AB  - Preclinical studies in porcine mechanical heart valve models suggested that dabigatran may effectively prevent valve thrombosis [Schomburg JL et al. J Invest Surg 2012]. These results led to A Randomized, Phase 2 Study to Evaluate the Safety and Pharmacokinetics of Oral Dabigatran Etexilate in Patients After Heart Valve Replacement [RE-ALIGN; Eikelboom JW et al. N Engl J Med 2013]. The aim of the RE-ALIGN trial was to evaluate a dosing algorithm of dabigatran based on the RE-LY study to prevent thromboembolic complications in patients with mechanical heart valve replacement.