RT Journal Article
SR Electronic
A1 Parry, Nicola
T1 PPAR-Mediated Mechanisms of Skeletal Muscle Insulin Resistance
JF MD Conference Express
YR 2013
FD SAGE Publications
VO 13
IS 16
SP 12
OP 13
DO 10.1177/155989771316010
UL http://mdc.sagepub.com/content/13/16/12.abstract
AB Skeletal muscle is the major site for insulin-dependent glucose utilization, and insulin resistance in skeletal muscle is thought to be integral in the pathogenesis of type 2 diabetes mellitus (T2DM). This article discusses some emerging insights into the molecular basis of skeletal muscle insulin resistance, highlighting the role of peroxisome proliferator activated receptor-gamma (PPAR-?), a nuclear transcription factor.