PT  - JOURNAL ARTICLE
AU  - Rizzo, Toni
ED  - Karpe, Fredrik
TI  - Oversupply of Free Fatty Acids to the Systemic Circulation is Not a Distinct Feature of Insulin Resistance or Obesity
DP  - 2013 Dec 01
TA  - MD Conference Express
PG  - 11--12
VI  - 13
IP  - 16
4099  - http://mdc.sagepub.com/content/13/16/11.short
4100  - http://mdc.sagepub.com/content/13/16/11.full
AB  - Measurements of free fatty acid (FFA), also known to as non-esterified fatty acid, and glucose kinetics have shown that obese individuals have adipose tissue that is insulin resistant [Jensen MD, Nielsen S. Metabolism 2007]. It is commonly thought that oversupply of FFA is a major contributor to the development of insulin resistance in obesity. This article discusses the known molecular mechanisms for the phenomenon of insulin resistance in adipose tissue and challenged the notion of oversupply of FFA in obesity.