PT  - JOURNAL ARTICLE
AU  - Rizzo, Toni
ED  - Kim, Jae Bum
TI  - Role of iNKT Cells in Adipose Tissue Inflammation and Insulin Resistance
DP  - 2013 Dec 01
TA  - MD Conference Express
PG  - 10--10
VI  - 13
IP  - 16
4099  - http://mdc.sagepub.com/content/13/16/10.1.short
4100  - http://mdc.sagepub.com/content/13/16/10.1.full
AB  - This article, presents results of experiments which suggest that invariant natural killer T (iNKT) cells decrease the adipose tissue inflammation. A study using transgenic mice fed a high-fat diet reported that infiltration of human resistin-expressing macrophages into adipose tissue is a key mechanism for development of accelerated adipose tissue inflammation [Qatanani M et al. Clin Invest 2009]. Resistin interacts with CAP1 on macrophages, stimulating the secretion of inflammatory cytokines that interferes with the normal insulin signaling pathway, demonstrating that adipose tissue inflammation may mediate insulin resistance.