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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/cdn\/css\/http\/css_Xg7z6oCTVgud_Q0huYz9x9iiD5H_2YPSJ5z2ZViSWdY.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003ENewly diagnosed patients with type 2 diabetes mellitus achieve lower HbA1C concentrations with a lower rate of hypoglycemia when started on triple therapy as opposed to stepwise add-on therapy. This article discusses results from a randomized open-label study comparing the two strategies.\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003EHyperglycemia\/Hypoglycemia\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EDiabetes Mellitus\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EDiabetes \u0026amp; Endocrinology Clinical Trials\u003C\/li\u003E\u003C\/ul\u003E\u003Cul class=\u0022kwd-group clinical-trial\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003EHyperglycemia\/Hypoglycemia\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EEndocrinology\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EDiabetes \u0026amp; Metabolic Syndrome\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EDiabetes Mellitus\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EDiabetes \u0026amp; Endocrinology Clinical Trials\u003C\/li\u003E\u003C\/ul\u003E\u003Cp id=\u0022p-2\u0022\u003ENewly diagnosed patients with type 2 diabetes mellitus (T2DM) achieve lower HbA1C concentrations with a lower rate of hypoglycemia when started on triple therapy as opposed to stepwise add-on therapy. Results from a randomized open-label study comparing the two strategies were announced by Ralph A. DeFronzo, MD, University of Texas Health Science Center, San Antonio, Texas, USA.\u003C\/p\u003E\u003Cp id=\u0022p-3\u0022\u003EThe optimal therapy to achieve HbA1C levels as close to normal as possible while avoiding hypoglycemia, as recommended by the American Diabetes Association and the European Association for the Study of Diabetes, has not been defined, said Dr. DeFronzo. In patients recently diagnosed with T2DM, beginning therapy with drugs that correct known pathophysiologic defects, in theory, should produce a greater, more durable reduction in HbA1C level while avoiding hypoglycemia rather than the currently recommended stepwise approach that can lower plasma glucose but does nothing to correct the underlying pathophysiology.\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003EThe efficacy and safety of initiating triple therapy (metformin\/pioglitazone\/exenatide) was compared with more conventional therapy that focuses on lowering plasma glucose with metformin followed by sequential addition of sulfonylurea and basal insulin to maintain HbA1C \u22646.5% in 169 newly diagnosed patients with T2DM. Patients were drug-na\u00efve, had a mean diabetes duration of 5.1 months and had a mean HbA1C level of 8.6% upon study entry. Medications could be down-titrated when fasting blood glucose levels dropped to \u0026lt;60 mg\/dL or the patient had symptoms of hypoglycemia.\u003C\/p\u003E\u003Cp id=\u0022p-5\u0022\u003EAt 24 months, HbA1C decreased to 5.9% in patients randomized to triple therapy and to 6.6% in those randomized to conventional therapy (p\u0026lt;0.001). Fasting and postprandial glucose levels were significantly lower in the triple-therapy arm compared with the conventional-therapy arm (p\u0026lt;0.01 for each). Ninety-two percent in the triple-therapy arm achieved an HbA1C \u0026lt;7.0% versus 72% in the conventional therapy arm (p\u0026lt;0.001) and 60% in the triple-therapy arm achieved a final HbA1C \u0026lt;6.0% versus 27% in the conventional arm (p\u0026lt;0.001). The cumulative failure rates (failure to achieve HbA1C \u22646.5%) were 42% in the conventional arm and 17% in the triple-therapy arm (p\u0026lt;0.001).\u003C\/p\u003E\u003Cp id=\u0022p-6\u0022\u003EOn multivariate regression analysis, triple therapy and older age were significant predictors of achieving an HbA1C \u22646.5% whereas higher baseline HbA1C and weight gain were significant predictors of treatment failure.\u003C\/p\u003E\u003Cp id=\u0022p-7\u0022\u003EDespite a significantly lower HbA1C level, subjects in the triple-therapy arm had nearly an 8-fold lower rate of hypoglycemia compared with those receiving conventional therapy (0.27 vs 2.1 events per subject per year; p\u0026lt;0.0001).\u003C\/p\u003E\u003Cp id=\u0022p-8\u0022\u003ESubjects in the triple-therapy arm experienced mean weight loss of 1.2 kg compared with mean weight gain of 4.1 kg (p\u0026lt;0.001) in subjects in the conventional-therapy arm.\u003C\/p\u003E\u003Cp id=\u0022p-9\u0022\u003EDr. DeFronzo concluded that triple therapy that targets the known pathophysiologic defects in new-onset T2DM produces a greater and more durable reduction in HbA1C with less hypoglycemia than conventional therapy with the added benefit of weight loss.\u003C\/p\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2013 MD Conference Express\u00ae\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/13\/17\/26.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nznlgd\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}