<?xml version='1.0' encoding='UTF-8'?><xml><records><record><source-app name="HighWire" version="7.x">Drupal-HighWire</source-app><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Cunningham, Muriel</style></author></authors><secondary-authors><author><style face="normal" font="default" size="100%">Kimmel, Stephen E.</style></author></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">COAG Trial: No Advantage Seen with Genetic-Based Warfarin Dosing</style></title><secondary-title><style face="normal" font="default" size="100%">MD Conference Express</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2013</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2013-12-01 00:00:00</style></date></pub-dates></dates><pages><style  face="normal" font="default" size="100%">22-22</style></pages><abstract><style  face="normal" font="default" size="100%">Warfarin is a widely used medication with a very narrow therapeutic window. Limited evidence suggests that utilizing pharmacogenetic information on top of clinical information could improve warfarin dosing, but large, well-conducted studies are lacking. This article discusses the key results of the Clarification of Optimal Anticoagulation Through Genetics trial [COAG; Kimmel SE et al. N Engl J Med 2013], which compared warfarin initiation using a clinical algorithm with or without the addition of pharmacogenetic information.</style></abstract><number><style face="normal" font="default" size="100%">20</style></number><volume><style face="normal" font="default" size="100%">13</style></volume></record></records></xml>