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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/cdn\/css\/http\/css_Xg7z6oCTVgud_Q0huYz9x9iiD5H_2YPSJ5z2ZViSWdY.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003EThe Evaluating Neuroprotection in Aneurysm Coiling Therapy trial [ENACT; \u003Ca class=\u0022external-ref external-ref-type-clintrialgov\u0022 href=\u0022\/lookup\/external-ref?link_type=CLINTRIALGOV\u0026amp;access_num=NCT00728182\u0026amp;atom=%2Fspmdc%2F12%2F1%2F20.atom\u0022\u003ENCT00728182\u003C\/a\u003E] showed that the novel agent NA-1 may be a useful treatment for stroke and ruptured aneurysm patients.\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003ECerebrovascular Disease Clinical Trials\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EInterventional Techniques \u0026amp; Devices\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EIschemia\u003C\/li\u003E\u003C\/ul\u003E\u003Cp id=\u0022p-2\u0022\u003EThe Evaluating Neuroprotection in Aneurysm Coiling Therapy trial [ENACT; \u003Ca class=\u0022external-ref external-ref-type-clintrialgov\u0022 href=\u0022\/lookup\/external-ref?link_type=CLINTRIALGOV\u0026amp;access_num=NCT00728182\u0026amp;atom=%2Fspmdc%2F12%2F1%2F20.atom\u0022\u003ENCT00728182\u003C\/a\u003E] showed that the novel agent NA-1 may be a useful treatment for stroke and ruptured aneurysm patients. Michael D. Hill, MD, MSc, FRCPC, University of Calgary, Calgary, Alberta, Canada, reported outcomes from the study.\u003C\/p\u003E\u003Cp id=\u0022p-3\u0022\u003EA randomized, multicenter, double-blind, placebo-controlled, single-dose Phase 2 trial, ENACT randomized 197 male and female patients who were undergoing endovascular repair of a brain aneurysm to receive 2.6 mg\/kg of NA-1 (n=92), a peptide designed to reduce ischemic brain damage, or placebo (n=93) as a 10-minute intravenous infusion after completion of the endovascular procedure on Day 1.\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003EThe primary outcome measures were to determine the safety and tolerability of a single IV dose of NA-1 in patients who were undergoing endovascular repair of brain aneurysms and establish the efficacy of NA-1 in reducing the volume of embolic strokes on enrollment and Days 1, 2\u20134, and 30. Secondary outcome measures were to determine the efficacy of a single IV dose of NA-1 in reducing the number of embolic strokes, procedurally induced vascular cognitive impairment, and frequency of large strokes on enrollment and Days 1, 2\u20134, and 30.\u003C\/p\u003E\u003Cp id=\u0022p-5\u0022\u003EOther than the number of past smokers (26.9% in controls versus 43.8% in the treatment group), baseline characteristics and treatment factors were similar between the two groups. Except for 2 adverse events of transient (15 minutes) mild hypotension, no serious adverse events were attributable to NA-1.\u003C\/p\u003E\u003Cp id=\u0022p-6\u0022\u003ECompared with baseline, the number and volume reductions of diffusion-weighted imaging (DWI) and fluid-attenuated inversion recovery (FLAIR) lesions in all subjects were significant (p=0.005 and p=0.026, respectively). In ruptured aneurysm patients, significant reductions in the number of DWI and FLAIR lesions were observed in the treatment and control groups (unadjusted p=0.027 and p=0.46, respectively); similarly, there were significant reductions in the volume of DWI and FLAIR lesions (unadjusted p=0.015 and p=0.023, respectively). In unruptured aneurysm subjects, there were significant reductions between the treatment and control groups in the number of DWI lesions (adjusted p=0.019).\u003C\/p\u003E\u003Cp id=\u0022p-7\u0022\u003EIn patients without large stroke, there were significant reductions in the number of DWI and FLAIR lesions (adjusted p=0.002 and p=0.012, respectively) as well as in volume (p=0.009 and p=0.014, respectively). Among proportions of patients with DWI lesions, binned at the 90\u003Csup\u003Eth\u003C\/sup\u003E percentile, more NA-1 subjects had 0 or 1 lesions; fewer had \u0026gt;15 lesions (p=0.012). Among subjects with ruptured aneurysms, 68.4% of controls and 100% of the treatment group had an NIHSS of 0 to 1 (p=0.020); 73.7% of controls and 94.4% of the treatment group had a modified Rankin scale score of 0 to 2. The relative risk was 1.3 (95% CI, 0.95 to 1.7; p=0.180).\u003C\/p\u003E\u003Cp id=\u0022p-8\u0022\u003EOverall, the trial showed that NA-1 was safe in patients with ruptured and unruptured aneurysms and reduced the number and volume of ischemic stroke lesions in a human model of iatrogenic embolic stroke. The study implies that neuroprotection is possible in older patients and that multiple endovascular procedures may be amenable to NA-1 treatment for stroke.\u003C\/p\u003E\u003Cp id=\u0022p-9\u0022\u003EThe authors concluded that testing of NA-1 in human community-acquired stroke is a priority and that it may be a useful treatment for ruptured aneurysm patients.\u003C\/p\u003E\u003Cdiv id=\u0022F1\u0022 class=\u0022fig pos-float  odd\u0022\u003E\u003Cdiv class=\u0022highwire-figure\u0022\u003E\u003Cdiv class=\u0022fig-inline-img-wrapper\u0022\u003E\u003Cdiv class=\u0022fig-inline-img\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/12\/1\/20\/F1.large.jpg?width=800\u0026amp;height=600\u0026amp;carousel=1\u0022 title=\u0022The editors would like to thank the many members of the International Stroke Conference 2012 presenting faculty who generously gave their time to ensure the accuracy and quality of the articles in this publication.\u0022 class=\u0022fragment-images colorbox-load\u0022 rel=\u0022gallery-fragment-images-389125464\u0022 data-figure-caption=\u0022The editors would like to thank the many members of the International Stroke Conference 2012 presenting faculty who generously gave their time to ensure the accuracy and quality of the articles in this publication.\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003E\u003Cimg class=\u0022fragment-image\u0022 alt=\u0022Figure1\u0022 src=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/12\/1\/20\/F1.medium.gif\u0022\/\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cul class=\u0022highwire-figure-links inline\u0022\u003E\u003Cli class=\u00220 first\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/12\/1\/20\/F1.large.jpg?download=true\u0022 class=\u0022highwire-figure-link highwire-figure-link-download\u0022 title=\u0022Download Figure1\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload figure\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00221\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/12\/1\/20\/F1.large.jpg\u0022 class=\u0022highwire-figure-link highwire-figure-link-newtab\u0022 target=\u0022_blank\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EOpen in new tab\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00222 last\u0022\u003E\u003Ca href=\u0022\/highwire\/powerpoint\/12721\u0022 class=\u0022highwire-figure-link highwire-figure-link-ppt\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload powerpoint\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003Cdiv class=\u0022fig-caption\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\n            \u003Cp id=\u0022p-10\u0022 class=\u0022first-child\u0022\u003EThe editors would like to thank the many members of the International Stroke Conference 2012 presenting faculty who generously gave their time to ensure the accuracy and quality of the articles in this publication.\u003C\/p\u003E\n         \u003Cdiv class=\u0022sb-div caption-clear\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2012 MD Conference Express\u00ae\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/12\/1\/20.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_figures.js?nzniwq\u0022\u003E\u003C\/script\u003E\n\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzniwq\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}