RT Journal Article SR Electronic A1 Buckley, Rita T1 RIS with Dissemination on MRI JF MD Conference Express YR 2012 FD SAGE Publications VO 12 IS 2 SP 9 OP 9 DO 10.1177/155989771202006 UL http://mdc.sagepub.com/content/12/2/9.1.abstract AB Although disease-modifying therapies work best when given early in MS, the decision to proactively treat patients with radiologically isolated syndrome (RIS) is countered by the increasing risks associated with disease-modifying therapies as well as the uncertain prognostic outcome of RIS [Spain R, Bourdette D. Curr Neurol Neurosci Rep 2011].