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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/advagg_css\/css__ce2QY63WIanKyr8eSq7eavr1XQRRmFD6ZSmwpyJi8lM__zXwFqpqmxrZOXXcd_TpBQpjuELbmIP9wBR5UuTDWAO4__YJWWMMdfCJuAFm5cUEp88OsodhO3ZA-2lzRfoBsSlk4.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003EThis article discusses outcomes from a study to examine the recovery dynamics of walking ability in multiple sclerosis patients during a three-month period after relapse.\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003ENeurology Clinical Trials\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EDemyelinating Diseases\u003C\/li\u003E\u003C\/ul\u003E\u003Cp id=\u0022p-2\u0022\u003ERehabilitation is important in maintaining and improving function in individuals with multiple sclerosis (MS), but there is no consensus on what may be the most effective approach to achieving the best possible functionality within a patient\u0027s limitations [Rasova K et al. \u003Cem\u003EHealth Qual Life Outcomes\u003C\/em\u003E 2010]. Moreover, there are few data on what constitutes a clinically significant change in a timed walk test after treatment for relapse [Coleman CI et al. \u003Cem\u003ECurr Med Res Opin\u003C\/em\u003E 2012]. K. Gross-Paju, MD, PhD, West-Tallinn Central Hospital, Tallinn, Estonia, presented outcomes from a study to examine the recovery dynamics of walking ability in MS patients during a three-month period after relapse.\u003C\/p\u003E\u003Cp id=\u0022p-3\u0022\u003EA total of 25 patients with relapsing-remitting MS were recruited. Four had two relapses during the study period. A total of 29 relapses were assessed; all were treated with 5 g of IV methylprednisolone (IVMP). Assessment measures included the Extended Disability Status Scale (EDSS), 6-Minute Walk Test (6MWT), and the Multiple Sclerosis Walking Scale (MSWS). Walking parameters were recorded during relapse after the first IVMP drip, the last IVMP drip, and at 1 and 3 months after relapse.\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003EPost-relapse EDSS scores improved at 1 and 3 months (p=0.0118 and p=0.0023, respectively). After the first IVMP drip, there was significant improvement in the 6MWT compared with relapse (6.5%; p\u22640.0001). Improvement increased up to 9% (p=0.0001) after the fifth IVMP drip, but remained unchanged at further follow-up. Outcomes on the MSWS followed a similar course: 20% improvement (p\u22640.0001) compared with relapse after the fifth IVMP drip, with no change during follow-up.\u003C\/p\u003E\u003Cp id=\u0022p-5\u0022\u003EData confirmed a significant improvement in the 6MWT after the first IVMP drip, which was sustained at 3-month follow-up. After the fifth IVMP drip, there was a 20% improvement in the MSWS, which was sustained up to 3 months.\u003C\/p\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2012 MD Conference Express\u00ae\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/12\/2\/8.2.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nznhzd\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}