PT  - JOURNAL ARTICLE
AU  - Vinall, Maria
ED  - Brignole, Michele
TI  - Pacemaker Therapy in Patients with Neurally Mediated Syncope and Documented Asystole
DP  - 2012 Jun 01
TA  - MD Conference Express
PG  - 14--15
VI  - 12
IP  - 4
4099  - http://mdc.sagepub.com/content/12/4/14.short
4100  - http://mdc.sagepub.com/content/12/4/14.full
AB  - This article presents evidence from the International Study on Syncope of Uncertain Etiology 3 Study [ISSUE3; NCT00359203], demonstrating that cardiac pacing therapy is effective for prevention of recurrent syncope in patients with neurally mediated syncope (NMS) and documented asystole. These data contradict previous data from two randomized trials [Connolly SJ et al. JAMA 2003; Raviele A et al. Eur Heart J 2004] that failed to prove the superiority of cardiac pacing over placebo for the prevention of syncopal recurrences in unselected patients who were affected by NMS.