<?xml version='1.0' encoding='UTF-8'?><xml><records><record><source-app name="HighWire" version="7.x">Drupal-HighWire</source-app><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Rizzo, Toni</style></author></authors><secondary-authors><author><style face="normal" font="default" size="100%">Törring, Ove</style></author></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">FREEDOM Trial Analysis: Denosumab Discontinuation and Associated Fracture Incidence</style></title><secondary-title><style face="normal" font="default" size="100%">MD Conference Express</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2012</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2012-08-01 00:00:00</style></date></pub-dates></dates><pages><style  face="normal" font="default" size="100%">28-28</style></pages><abstract><style  face="normal" font="default" size="100%">Patients with osteoporosis who discontinue denosumab have transient increases in bone remodeling and decreases in bone mineral density [Miller PD et al. Bone 2008; Bone HG et al. J Clin Endocrinol Metab 2011], but the effect of discontinuation on fracture risk is not clear. The Phase 3 Fracture Reduction Evaluation of Denosumab in Osteoporosis Every 6 Months [FREEDOM; NCT00089791] trial determined the incidence of fractures in postmenopausal patients with osteoporosis after stopping denosumab therapy.</style></abstract><number><style face="normal" font="default" size="100%">9</style></number><volume><style face="normal" font="default" size="100%">12</style></volume></record></records></xml>