RT Journal Article SR Electronic A1 Rizzo, Toni T1 Adalimumab Plus Methotrexate versus Methotrexate Monotherapy in Early RA JF MD Conference Express YR 2012 FD SAGE Publications VO 12 IS 9 SP 16 OP 16 DO 10.1177/155989771209013 UL http://mdc.sagepub.com/content/12/9/16.1.abstract AB This article presents results from the High Induction Therapy with Anti-Rheumatic Drugs study [HIT HARD], which compared treatment with adalimumab plus methotrexate with methotrexate monotherapy in disease-modifying antirheumatic drug (DMARD)-naïve patients with active early rheumatoid arthritis (RA). The central question of the study was whether or not early induction therapy with a subsequent step-down strategy leads to long-term clinical effect in patients with RA.