PT  - JOURNAL ARTICLE
AU  - Buckley, Rita
ED  - Bay-Jensen, Anne C.
TI  - LITHE Study Subset: Identification of Tocilizumab Early Response-Associated Biomarkers
DP  - 2012 Sep 01
TA  - MD Conference Express
PG  - 15--15
VI  - 12
IP  - 9
4099  - http://mdc.sagepub.com/content/12/9/15.short
4100  - http://mdc.sagepub.com/content/12/9/15.full
AB  - The protein fragments that are generated from metalloproteinase (MMP)-mediated protein destruction are known as neoepitopes, which serve as biomarkers of inflammation in patients with rheumatoid arthritis (RA). The aim of Randomized, Double-Blind Study of Safety and Prevention of Structural Joint Damage During Treatment With Tocilizumab Versus Placebo, in Combination With Methotrexate, in Patients With Moderate to Severe Rheumatoid Arthritis study [LITHE; NCT00106535] was to identify biomarker profiles that are associated with early response to tocilizumab in patients with RA, using neoepitope markers.