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xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003EDuring the 2012 EULAR meeting, \u2018MD Conference Express\u2019 met with Maxime Dougados, MD, EULAR 2012 President, to discuss how the new research findings presented at EULAR and how those findings can be translated into daily practice.\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003ERheumatology\u003C\/li\u003E\u003C\/ul\u003E\u003Cdiv id=\u0022F1\u0022 class=\u0022fig pos-float  odd\u0022\u003E\u003Cdiv class=\u0022highwire-figure\u0022\u003E\u003Cdiv class=\u0022fig-inline-img-wrapper\u0022\u003E\u003Cdiv class=\u0022fig-inline-img\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/12\/9\/6\/F1.large.jpg?width=800\u0026amp;height=600\u0026amp;carousel=1\u0022 title=\u0022\u0022 class=\u0022fragment-images colorbox-load\u0022 rel=\u0022gallery-fragment-images-1790927996\u0022 data-figure-caption=\u0022\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003E\u003Cimg class=\u0022fragment-image\u0022 alt=\u0022Figure1\u0022 src=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/12\/9\/6\/F1.medium.gif\u0022\/\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cul class=\u0022highwire-figure-links inline\u0022\u003E\u003Cli class=\u00220 first\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/12\/9\/6\/F1.large.jpg?download=true\u0022 class=\u0022highwire-figure-link highwire-figure-link-download\u0022 title=\u0022Download Figure1\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload figure\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00221\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/12\/9\/6\/F1.large.jpg\u0022 class=\u0022highwire-figure-link highwire-figure-link-newtab\u0022 target=\u0022_blank\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EOpen in new tab\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00222 last\u0022\u003E\u003Ca href=\u0022\/highwire\/powerpoint\/14250\u0022 class=\u0022highwire-figure-link highwire-figure-link-ppt\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload powerpoint\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cp id=\u0022p-2\u0022\u003EDuring the 2012 EULAR meeting, \u003Cem\u003EMD Conference Express\u003C\/em\u003E met with Maxime Dougados, MD, EULAR 2012 President, to discuss how the new research findings presented at EULAR and how those findings can be translated into daily practice.\u003C\/p\u003E\u003Cp id=\u0022p-3\u0022\u003EMD Conference Express: \u003Cem\u003EProf. Dougados, congratulations on such a successful meeting\u003C\/em\u003E.\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003EProf. Dougados: Thank you. All of us on the committee are very pleased with this year\u0027s meeting. As you know, our goals are to provide a forum for the exchange of the highest quality clinical and basic science, encourage an educational and social exchange between professionals involved in rheumatology, as well as to liaise with patient organizations. We are particularly pleased that this year we have expanded the times available for the basic science session, and we have added two new initiatives to our educational program in the form of the \u201cWhat is New?\u201d (WIN) and \u201cHow to Treat\u201d (HOT) sessions.\u003C\/p\u003E\u003Cp id=\u0022p-5\u0022\u003EThe EULAR meeting is an excellent opportunity to present new data that will ultimately affect daily practice, not tomorrow morning but perhaps in a few years. I personally think the IL-20 monoclonal antibody is interesting conceptually and is a story to follow. The Janus kinase (JAK) inhibitors are interesting, as well; of particular interest is the specificity of JAK inhibition and its impact on hematopoiesis. As I\u0027m sure you know, some criticism has been directed at the field of rheumatology lately concerning the lack of head-to-head trials of biologics. Several of these are being reported at this year\u0027s meeting. The information they bring to clinicians is certainly useful. Personally, however, I think it\u0027s much more interesting for daily practice if we can personalize medicine. So I would like to see more data looking at the predisposing factors of treatment response.\u003C\/p\u003E\u003Cp id=\u0022p-6\u0022\u003EMD Conference Express: \u003Cem\u003ETell us more about the presentation concerning the validation of the 2010 ACR\/EULAR classification criteria. What have we learned?\u003C\/em\u003E\n      \u003C\/p\u003E\u003Cp id=\u0022p-7\u0022\u003EProf. Dougados: Sometimes I think the new criteria are being misinterpreted. To fulfill the criteria, the physician must first detect synovitis. The second step is to determine if another etiology is involved (for example septic arthritis, systemic lupus erythematosus or gout). If there is no other clear explanation for the synovitis, then the third step is to check the x-rays. If erosion is found, at this point, the diagnosis is confirmed; if not, that is when the criteria table comes into use. This potential for misinterpretation\u2014for clinicians to want to go directly to the \u201cmagic table\u201d\u2014is why EULAR has formed a task force to precisely define what we call erosion when we are evaluating the 2010 ACR\/EULAR classification criteria.\u003C\/p\u003E\u003Cp id=\u0022p-8\u0022\u003EMD Conference Express: \u003Cem\u003ERecent studies have tried to validate the concept of Treat to Target (T2T). Have they succeeded?\u003C\/em\u003E\n      \u003C\/p\u003E\u003Cp id=\u0022p-9\u0022\u003EProf. Dougados: Yes, I think so. In France, we have a cohort of 813 patients with early synovitis (the ESPOIR cohort) from 20 centers. Last month. we published the results of an analysis that examined the association between adherence to the 2007 EULAR recommendations for managing early arthritis and radiographic progression and disability. Our results clearly showed that if you have rheumatoid arthritis, and you are monitored by a doctor who adheres to the T2T approach, you will be three times less likely to be disabled 3 years later.\u003C\/p\u003E\u003Cp id=\u0022p-10\u0022\u003EWe have plenty of data suggesting that the T2T concept is working, but the question of what the target should be We have. A number of people are looking at that, including the Targeted Ultrasonography Initiative, which is a group of international experts who support a target of active synovitis on ultrasonography as opposed to using the Disease Activity Score. Laure Gossec, MD, PhD, presented an interesting study this week, also from the ESPOIR cohort, showing the importance of inflammation, but not patient-reported global or fatigue scores, in predicting progression over 3 years.\u003C\/p\u003E\u003Cp id=\u0022p-11\u0022\u003EMD Conference Express: \u003Cem\u003EWhat are the most promising novel targets for rheumatoid arthritis?\u003C\/em\u003E\n      \u003C\/p\u003E\u003Cp id=\u0022p-12\u0022\u003EProf. Dougados: Right now, everyone is thinking about JAKs, but right behind them (in about 1 or 2 years, at least in the US and Europe) are IL-17, maybe IL-20.\u003C\/p\u003E\u003Cp id=\u0022p-13\u0022\u003EMD Conference Express: \u003Cem\u003EThank you, for your time Prof. Dougados\u003C\/em\u003E.\u003C\/p\u003E\u003Cp id=\u0022p-14\u0022\u003EProf. Dougados: It has been my pleasure.\u003C\/p\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2012 MD Conference Express\u00ae\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/12\/9\/6.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_figures.js?nznfo2\u0022\u003E\u003C\/script\u003E\n\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nznfo2\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}