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Inflammation and Vascular Injury

Summary

The focus this article is on a class of leukocyte adhesion molecules, leukocyte β2-integrins, among which Mac-1 (aMb2, CD11b/CD18) is the most common integrin on neutrophils. The leukocyte Mac-1 receptor interacts with the glyocoprotein Iba (GPIba) receptor on platelets, thereby regulating pro-inflammatory and pro-thrombotic bidirectional signals in both inflammatory cells and platelets.

  • Inflammatory Disease
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