PT  - JOURNAL ARTICLE
AU  - Rizzo, Toni
ED  - Tomaselli, Gordon F.
TI  - Electrical Remodeling in Heart Failure
DP  - 2012 Oct 01
TA  - MD Conference Express
PG  - 13--13
VI  - 12
IP  - 3
4099  - http://mdc.sagepub.com/content/12/3/13.short
4100  - http://mdc.sagepub.com/content/12/3/13.full
AB  - Cardiac resynchronization therapy (CRT) improves heart failure (HF) symptoms, ventricular performance, and myocardial efficiency. Researchers have studied the effect of CRT on cardiac remodeling in HF using a canine model of HF with 3 to 4 weeks of 240 bpm right ventricular pacing and left-ventricular diastolic end pressure of 30 to 45 mm Hg. Electrical changes included prolonged action potential duration, a hallmark of HF, and increased difference between the longest and shortest action potentials at slower rates.