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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/advagg_css\/css__ce2QY63WIanKyr8eSq7eavr1XQRRmFD6ZSmwpyJi8lM__zXwFqpqmxrZOXXcd_TpBQpjuELbmIP9wBR5UuTDWAO4__YJWWMMdfCJuAFm5cUEp88OsodhO3ZA-2lzRfoBsSlk4.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003EOptical coherence tomography (OCT) is a low-penetration imaging technique with 10 \u03bcm to 15 \u03bcm resolution that can be used to view atherosclerotic plaque. Unlike intravascular ultrasound (IVUS), OCT can identify inflammatory cells (macrophages) in plaque. This article discussed assessment of atherosclerotic plaque and drug-eluting stents with OCT.\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003EImaging Modalities\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ECardiac Imaging Techniques\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ECoronary Artery Disease\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ERadiography\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EInterventional Techniques \u0026amp; Devices\u003C\/li\u003E\u003C\/ul\u003E\u003Cp id=\u0022p-2\u0022\u003EOptical coherence tomography (OCT) is a low-penetration imaging technique with 10 \u03bcm to 15 \u03bcm resolution that can be used to view atherosclerotic plaque. Unlike intravascular ultrasound (IVUS), OCT can identify inflammatory cells (macrophages) in plaque. Time-domain OCT (TD-OCT) and the newer frequency-domain OCT (FD-OCT) have similar resolution and penetration, but FD-OCT has more lines per frame and faster pullback speed and frame rate, resulting in better images. Luca Di Vito, MD, PhD, San Giovanni Hospital, Rome, Italy, discussed assessment of atherosclerotic plaque and drug-eluting stents (DES) with OCT.\u003C\/p\u003E\u003Cdiv class=\u0022section\u0022 id=\u0022sec-1\u0022\u003E\n         \u003Ch2 class=\u0022\u0022\u003EPre- and Post-DES Assessment\u003C\/h2\u003E\n         \u003Cp id=\u0022p-3\u0022\u003EOCT signal analysis depends on signal attenuation and backscattering to visualize the edge sharpness and texture of plaques. An important use for OCT is to identify vulnerable plaque such as thin-cap fibroatheroma (TCFA), characterized by a thin fibrous cap with a large lipid core, micro-vessels, and inflammatory cells. Vulnerable plaque may undergo rupture that in turn can cause thrombus formation. OCT can distinguish between red (high attenuation) and white (low attenuation) thrombi that are respectively composed by red blood cells and platelets.\u003C\/p\u003E\n         \u003Cp id=\u0022p-4\u0022\u003EOCT is useful for assessing stent deployment and can identify intrastent and edge dissection, tissue prolapse, and intra-stent thrombus. Dr. Di Vito\u0027s group assessed 21 patients who had experienced type IVa myocardial infarction (MI) and 29 controls with FD-OCT before and after percutaneous coronary intervention (PCI) [Porto I et al. \u003Cem\u003ECirc Cardiovasc Interv\u003C\/em\u003E 2012]. Pre-PCI assessment demonstrated that TCFA was significantly associated with type IVa MI (p=0.017). Post-PCI analysis demonstrated significantly more frequent intra-stent thrombus (p=0.04) and intra-stent dissection (p=0.03) in type IVa MI patients versus controls. Multivariate analysis showed an association between type IVa MI and TCFA (OR, 29.79; 95% CI, 1.36 to 32.08; p=0.008), intra-stent thrombus (OR, 5.55; 95% CI, 1.24 to 24.86; p=0.025), and intra-stent dissection (OR, 5.33; 95% CI, 1.16 to 24.34; p=0.031). There was no association between type IVa MI and presenting thrombus, ruptured plaque, or plaque tissue prolapse.\u003C\/p\u003E\n         \u003Cp id=\u0022p-5\u0022\u003EProf. Di Vito concluded that TCFA, intra-stent thrombus, and intra-stent dissection are independent predictors of type IVa MI. Plaque-derived or friable thrombotic debris cause type IVa MI. Tissue prolapse through stent struts probably does not cause embolic events. Importantly, 2 of the 3 predictors of type IVa MI were not identified before PCI.\u003C\/p\u003E\n         \u003Cp id=\u0022p-6\u0022\u003EProf. Di Vito also explored the use of OCT for assessing the new-generation bioresorbable vascular scaffold (BVS) DES. So far, BVS results were similar to results for other DES. Prof. Di Vito concluded that conventional and new-generation DES can be assessed by OCT. These studies show that analysis of pre- and post-PCI OCT images can improve PCI outcomes.\u003C\/p\u003E\n         \u003Cdiv id=\u0022F1\u0022 class=\u0022fig pos-float  odd\u0022\u003E\u003Cdiv class=\u0022highwire-figure\u0022\u003E\u003Cdiv class=\u0022fig-inline-img-wrapper\u0022\u003E\u003Cdiv class=\u0022fig-inline-img\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/12\/3\/12\/F1.large.jpg?width=800\u0026amp;height=600\u0026amp;carousel=1\u0022 title=\u0022The editors would like to thank the many members of the Japanese Circulation Society presenting faculty who generously gave their time to ensure the accuracy and quality of the articles in this publication.\u0022 class=\u0022fragment-images colorbox-load\u0022 rel=\u0022gallery-fragment-images-906916003\u0022 data-figure-caption=\u0022The editors would like to thank the many members of the Japanese Circulation Society presenting faculty who generously gave their time to ensure the accuracy and quality of the articles in this publication.\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003E\u003Cimg class=\u0022fragment-image\u0022 alt=\u0022Figure1\u0022 src=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/12\/3\/12\/F1.medium.gif\u0022\/\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cul class=\u0022highwire-figure-links inline\u0022\u003E\u003Cli class=\u00220 first\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/12\/3\/12\/F1.large.jpg?download=true\u0022 class=\u0022highwire-figure-link highwire-figure-link-download\u0022 title=\u0022Download Figure1\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload figure\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00221\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/12\/3\/12\/F1.large.jpg\u0022 class=\u0022highwire-figure-link highwire-figure-link-newtab\u0022 target=\u0022_blank\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EOpen in new tab\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00222 last\u0022\u003E\u003Ca href=\u0022\/highwire\/powerpoint\/13980\u0022 class=\u0022highwire-figure-link highwire-figure-link-ppt\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload powerpoint\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003Cdiv class=\u0022fig-caption\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\n               \u003Cp id=\u0022p-7\u0022 class=\u0022first-child\u0022\u003EThe editors would like to thank the many members of the Japanese Circulation Society presenting faculty who generously gave their time to ensure the accuracy and quality of the articles in this publication.\u003C\/p\u003E\n            \u003Cdiv class=\u0022sb-div caption-clear\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\n      \u003C\/div\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2012 MD Conference Express\u00ae\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/12\/3\/12.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_figures.js?nznea1\u0022\u003E\u003C\/script\u003E\n\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nznea1\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}