RT Journal Article
SR Electronic
A1 Rizzo, Toni
T1 Safety and Efficacy of Anticoagulants
JF MD Conference Express
YR 2012
FD SAGE Publications
VO 12
IS 6
SP 19
OP 20
DO 10.1177/155989771206013
UL http://mdc.sagepub.com/content/12/6/19.abstract
AB Apixaban is an oral factor Xa inhibitor with prompt onset and offset of anticoagulation, twice-a-day dosing, and no need for coagulation monitoring. This article discusses the efficacy and safety of apixaban compared with warfarin in ARISTOTLE trial, and with aspirin in AVERROES Trial. This article also discusses the challenge of choosing anticoagulation therapy for patients with AF using the RE-LY, ROCKET, ARISTOTLE, and ENGAGE AF-TIMI 48 as examples.