PT - JOURNAL ARTICLE AU - Rizzo, Toni ED - Sadaka, Mohamed TI - FAME-Trials Family: Physiology, Decision-Making, and Clinical Outcomes DP - 2012 Dec 01 TA - MD Conference Express PG - 8--9 VI - 12 IP - 8 4099 - http://mdc.sagepub.com/content/12/8/8.short 4100 - http://mdc.sagepub.com/content/12/8/8.full AB - This article discusses the use of fractional flow reserve (FFR) with angiography for detecting significant coronary artery stenosis. FFR is the only functional index that has been validated against a true gold standard. All studies performed in a wide range of clinical and angiographic conditions found an FFR threshold of 0.75 to 0.80 to detect significant stenosis, with a sensitivity of 90% and specificity of 100% [Pijls NHJ et al. N Engl J Med 1996].