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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/advagg_css\/css__ce2QY63WIanKyr8eSq7eavr1XQRRmFD6ZSmwpyJi8lM__zXwFqpqmxrZOXXcd_TpBQpjuELbmIP9wBR5UuTDWAO4__YJWWMMdfCJuAFm5cUEp88OsodhO3ZA-2lzRfoBsSlk4.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003EThere is a need for new antibiotics to treat the rising incidence of community-acquired bacterial pneumonia (CABP) and acute bacterial skin and skin structure infections caused by Gram-positive bacteria such as Streptococcus pneumoniae and Staphylococcus aureus, including the multidrug resistant and methicillin-resistant (MRSA) forms of these bacteria. This article presents a poster [Jandourek et al. ICAAC 2012 L1\u2013300c] with results from the Clinical Assessment Program and Teflaro\u00ae Utilization Registry cohort [CAPTURE] study that showed ceftaroline produced good clinical outcomes when used as monotherapy to treat CABP due to MRSA.\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003EBacterial Infections\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EInfectious Disease Clinical Trials\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EDrug Resistance\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EPneumonia\u003C\/li\u003E\u003C\/ul\u003E\u003Cp id=\u0022p-2\u0022\u003EThere is a need for new antibiotics to treat the rising incidence of community-acquired bacterial pneumonia (CABP) and acute bacterial skin and skin structure infections (ABSSSI) caused by Gram-positive bacteria such as \u003Cem\u003EStreptococcus pneumoniae\u003C\/em\u003E and \u003Cem\u003EStaphylococcus aureus\u003C\/em\u003E, including the multidrug resistant (MDRSP) and methicillin-resistant (MRSA) forms of these bacteria. Ceftaroline (CPT) fosamil is an injectable novel cephalosporin antibiotic approved by the FDA to treat CABP and ABSSSI. Alena Jandourek, MD, Cerexa, Inc., Oakland, California, USA, presented a poster [Jandourek et al. ICAAC 2012 L1\u2013300c] with results from the Clinical Assessment Program and Teflaro\u00ae Utilization Registry cohort [CAPTURE] study that showed CPT produced good clinical outcomes when used as monotherapy to treat CABP due to MRSA.\u003C\/p\u003E\u003Cp id=\u0022p-3\u0022\u003ECAPTURE was a multicenter, retrospective chart review conducted to document outcomes in patients with CABP due to MRSA isolated from sputum and\/or blood after CPT treatment. A successful outcome was defined as clinical improvement resulting in either a change to oral agents or end of antibacterial therapy. Men and women \u226518 years of age, diagnosed with CABP, and receiving \u22652 consecutive IV doses of CPT per the institution\u0027s standard of care between January 2011 and 2012 were included. Data collected included pathogens cultured, concomitant antibacterials, comorbid conditions, and relevant past medical history, admission, and discharge information.\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003EOut of 70 patients enrolled with CAPB, 10 patients (mean age 68.5 years; range 52 to 85 years) had MRSA CABP. Nine patients had MRSA only and 1 patient had methicillin-sensitive \u003Cem\u003EStaphylococcus aureus\u003C\/em\u003E (MSSA) and MRSA. All patients had comorbidities, including structural lung disease, prior pneumonia, history of smoking, cancer, congestive heart failure, gastroesophageal reflux disease, and cerebrovascular accident. Eight patients were treated with other antibacterial therapy prior to CPT. CPT was dosed at 600 mg every 12 hours for a median duration of 6.5 days (range 4 to 30); 3 patients received adjunctive antibacterial therapy. Clinical success was reported in 7 patients. The patient with MSSA and MRSA was discharged home after 9 days. Two of the 3 patients with treatment failure had end-stage cancer and both were transitioned to palliative care. The third patient was treated with multiple antibacterials, then changed to CPT, and later switched to clindamycin.\u003C\/p\u003E\u003Cp id=\u0022p-5\u0022\u003ELimitations of this study include the bias associated with a retrospective cohort study and imprecise reporting of prior antimicrobial therapy dates and dates of cultures collection\/results. Dr. Jandourek concluded by noting that despite the presence of significant comorbidities and severe disease, the good clinical outcomes in this study suggest that the use of CPT in MRSA CABP warrants further investigation.\u003C\/p\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2012 MD Conference Express\u00ae\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/12\/14\/17.1.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzn9f1\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}