RT Journal Article SR Electronic A1 Nichols, Emma Hitt T1 Biologically Based Treatment in Head and Neck Squamous Cell Carcinoma JF MD Conference Express YR 2012 FD SAGE Publications VO 12 IS 15 SP 16 OP 17 DO 10.1177/155989771215012 UL http://mdc.sagepub.com/content/12/15/16.abstract AB This article discusses the concept of window-of-opportunity studies in relation to squamous cell cancers of the head and neck. Also discussed are predictors of sensitivity and resistance mechanisms, a review of poly (adenosine diphosphate-ribose) polymerase inhibitors and strategies in chemoradiation.