Summary

Disodium ethylene diamine tetra acetic acid (EDTA) binds divalent cations and permits renal excretion. The data for chelation have been mixed with some case reports and case series reporting benefit and other studies suggesting no benefit or even harm, particularly when rapid infusions cause hypocalcemia. This article reports the results of the Trial to Assess Chelation Therapy [TACT; NCT00044213].