PT  - JOURNAL ARTICLE
AU  - Vinall, Maria
ED  - Lafyatis, Robert
TI  - Anti-TGFβ Inhibits TGFβ-Regulated Gene Expression in Skin and Is Associated with a Rapid Decline in Skin Score
DP  - 2012  01
TA  - MD Conference Express
PG  - 21--22
VI  - 12
IP  - 19
4099  - http://mdc.sagepub.com/content/12/19/21.2.short
4100  - http://mdc.sagepub.com/content/12/19/21.2.full
AB  - In scleroderma, drug treatment of skin disease is difficult to assess due to the lack of easily measured endpoints. The modified Rodnan skin score (mRSS) is one method used to differentiate systemic sclerosis (SSc) disease subtypes, but it does not change much over short periods. This article discusses results from the Fresolimumab in Systemic Sclerosis [NCT01284322] study showing that transforming growth factor-β a-response genes correlate with the mRSS and may provide a means to more quickly assess drug efficacy for skin fibrosis in early phase trials.