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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/advagg_css\/css__ce2QY63WIanKyr8eSq7eavr1XQRRmFD6ZSmwpyJi8lM__zXwFqpqmxrZOXXcd_TpBQpjuELbmIP9wBR5UuTDWAO4__YJWWMMdfCJuAFm5cUEp88OsodhO3ZA-2lzRfoBsSlk4.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003ETreatment with the oral Janus kinase (JAK) inhibitor tofacitinib was associated with an improvement in the signs and symptoms of rheumatoid arthritis (RA), physical function, and patient reported outcomes in RA patients with an inadequate response to tumor necrosis factor inhibitors (TNFi). The improved response was maintained over 24 months.\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003ERheumatology Clinical Trials\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ERheumatoid Arthritis\u003C\/li\u003E\u003C\/ul\u003E\u003Cp id=\u0022p-2\u0022\u003ETreatment with the oral Janus kinase (JAK) inhibitor tofacitinib was associated with an improvement in the signs and symptoms of rheumatoid arthritis (RA), physical function, and patient reported outcomes in RA patients with an inadequate response to tumor necrosis factor inhibitors (TNFi). The improved response was maintained over 24 months. Data from 11 studies [Monotherapy: \u003Ca class=\u0022external-ref external-ref-type-clintrialgov\u0022 href=\u0022\/lookup\/external-ref?link_type=CLINTRIALGOV\u0026amp;access_num=NCT00550446\u0026amp;atom=%2Fspmdc%2F12%2F19%2F18.1.atom\u0022\u003ENCT00550446\u003C\/a\u003E,  \u003Ca class=\u0022external-ref external-ref-type-clintrialgov\u0022 href=\u0022\/lookup\/external-ref?link_type=CLINTRIALGOV\u0026amp;access_num=NCT00687193\u0026amp;atom=%2Fspmdc%2F12%2F19%2F18.1.atom\u0022\u003ENCT00687193\u003C\/a\u003E,  \u003Ca class=\u0022external-ref external-ref-type-clintrialgov\u0022 href=\u0022\/lookup\/external-ref?link_type=CLINTRIALGOV\u0026amp;access_num=NCT00814307\u0026amp;atom=%2Fspmdc%2F12%2F19%2F18.1.atom\u0022\u003ENCT00814307\u003C\/a\u003E; background DMARD: \u003Ca class=\u0022external-ref external-ref-type-clintrialgov\u0022 href=\u0022\/lookup\/external-ref?link_type=CLINTRIALGOV\u0026amp;access_num=NCT00413660\u0026amp;atom=%2Fspmdc%2F12%2F19%2F18.1.atom\u0022\u003ENCT00413660\u003C\/a\u003E,  \u003Ca class=\u0022external-ref external-ref-type-clintrialgov\u0022 href=\u0022\/lookup\/external-ref?link_type=CLINTRIALGOV\u0026amp;access_num=NCT00603512\u0026amp;atom=%2Fspmdc%2F12%2F19%2F18.1.atom\u0022\u003ENCT00603512\u003C\/a\u003E,  \u003Ca class=\u0022external-ref external-ref-type-clintrialgov\u0022 href=\u0022\/lookup\/external-ref?link_type=CLINTRIALGOV\u0026amp;access_num=NCT00960440\u0026amp;atom=%2Fspmdc%2F12%2F19%2F18.1.atom\u0022\u003ENCT00960440\u003C\/a\u003E,  \u003Ca class=\u0022external-ref external-ref-type-clintrialgov\u0022 href=\u0022\/lookup\/external-ref?link_type=CLINTRIALGOV\u0026amp;access_num=NCT00847613\u0026amp;atom=%2Fspmdc%2F12%2F19%2F18.1.atom\u0022\u003ENCT00847613\u003C\/a\u003E,  \u003Ca class=\u0022external-ref external-ref-type-clintrialgov\u0022 href=\u0022\/lookup\/external-ref?link_type=CLINTRIALGOV\u0026amp;access_num=NCT00856544\u0026amp;atom=%2Fspmdc%2F12%2F19%2F18.1.atom\u0022\u003ENCT00856544\u003C\/a\u003E,  \u003Ca class=\u0022external-ref external-ref-type-clintrialgov\u0022 href=\u0022\/lookup\/external-ref?link_type=CLINTRIALGOV\u0026amp;access_num=NCT00853385\u0026amp;atom=%2Fspmdc%2F12%2F19%2F18.1.atom\u0022\u003ENCT00853385\u003C\/a\u003E; LTE: \u003Ca class=\u0022external-ref external-ref-type-clintrialgov\u0022 href=\u0022\/lookup\/external-ref?link_type=CLINTRIALGOV\u0026amp;access_num=NCT00413699\u0026amp;atom=%2Fspmdc%2F12%2F19%2F18.1.atom\u0022\u003ENCT00413699\u003C\/a\u003E,  \u003Ca class=\u0022external-ref external-ref-type-clintrialgov\u0022 href=\u0022\/lookup\/external-ref?link_type=CLINTRIALGOV\u0026amp;access_num=NCT00661661\u0026amp;atom=%2Fspmdc%2F12%2F19%2F18.1.atom\u0022\u003ENCT00661661\u003C\/a\u003E] were pooled and Gerd R. Burmester, MD, Charit\u00e9 University Hospital, Berlin, Germany, presented the results.\u003C\/p\u003E\u003Cp id=\u0022p-3\u0022\u003EIn a prior study, tofacitinib improved the signs and symptoms of RA in 399 TNFi treatment refractory patients over 6 months [Burmester G-R et al. \u003Cem\u003EArthritis Rheum\u003C\/em\u003E 2011]. The purpose of this analysis was to provide additional short-and long-term data concerning the effect of tofacitinib on the signs and symptoms of RA, physical function, pain, and fatigue compared with placebo in this patient population and to further characterize the activity of tofacitinib by number of failed TNFi, by reason for failure (adverse event vs lack of efficacy). In the newer study, data from 9 randomized Phase 2 and 3 studies (n=614) and 2 open-label long-term extension studies (n=510) were analyzed. Patients were treated with tofacitinib (5 or 10 mg BID) either as monotherapy or on a background of nonbiologic disease-modifying antirheumatic drugs (DMARDs), or, in Phase 2 and 3 studies, with placebo.\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003EEfficacy in reducing the signs and symptoms of RA was assessed by changes in American College of Rheumatology improvement response criteria (ACR20\/50\/70) and 28-joint Disease Activity Score (DAS28)-4 erythrocyte sedimentation rate (ESR) scores. Physical function was assessed by mean change from baseline in Health Assessment Questionnaire Disability Index (HAQ-DI). Pain and fatigue were assessed using change from baseline on the Short Form-36 Bodily Pain item and the Functional Assessment of Chronic Illness Therapy-Fatigue item. More than 60% of the patients had failed at least one TNFi in all groups.\u003C\/p\u003E\u003Cp id=\u0022p-5\u0022\u003EAt Month 3, significantly greater ACR20\/50\/70 responder rates were seen with tofacitinib compared with placebo (p\u0026lt;0.0001, p\u0026lt;0.0001, p\u0026lt;0.05, respectively). This pattern was consistent regardless of 1 or 2 prior TNFi failures. Tofacitinib also improved mean DAS28\u20134 ESR scores, values for HAQ-DI, and body pain and fatigue at 3 months and over 24 months. No new safety signals were detected in the previously presented randomized controlled trial in TNFi inadequate response patients treated with tofacitinib [Burmester GR et al. \u003Cem\u003EArthritis Rheum\u003C\/em\u003E 2011].\u003C\/p\u003E\u003Cp id=\u0022p-6\u0022\u003EThe investigators concluded that tofacitinib may offer a benefit in difficult-to-treat patients resistant to standard DMARDs.\u003C\/p\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2012 MD Conference Express\u00ae\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/12\/19\/18.1.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzn5hd\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}