RT Journal Article SR Electronic A1 Vinall, Maria T1 Combination Full-Dose IV-tPA + Argatroban is Safe and May Result in Higher Rates of Recanalization JF MD Conference Express YR 2011 FD SAGE Publications VO 11 IS 1 SP 17 OP 18 DO 10.1177/155989771101011 UL http://mdc.sagepub.com/content/11/1/17.2.abstract AB Argatroban is a direct thrombin inhibitor that safely augments the benefit of tPA in animal stroke models; however, human data are limited. The Argatroban tPA Stroke Study [ARTSS; NCT00268762] is a multicenter, Phase II, prospective, open-label, safety and activity study of argatroban and tPA in patients with ischemic stroke.