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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/cdn\/css\/http\/css_Xg7z6oCTVgud_Q0huYz9x9iiD5H_2YPSJ5z2ZViSWdY.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003EResults of the ATRIA Study, a long-term follow-up study in patients with atrial fibrillation, demonstrated that deficit severity is a strong predictor of long-term poststroke survival.\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003ECerebrovascular Disease Clinical Trials\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ECerebrovascular Disease\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EArrhythmias\u003C\/li\u003E\u003C\/ul\u003E\u003Cp id=\u0022p-2\u0022\u003EResults of a long-term follow-up study in patients with atrial fibrillation (AF), presented by Margaret C. Fang, MD, PhD, University of California, San Francisco, California, demonstrated that deficit severity is a strong predictor of long-term poststroke survival.\u003C\/p\u003E\u003Cp id=\u0022p-3\u0022\u003EAF increases the risk for ischemic stroke approximately 5-fold and causes an estimated 15% of all strokes in the United States [Wolf PA et al. \u003Cem\u003EStroke\u003C\/em\u003E 1991]. Studies of AF-related stroke typically describe only short-term (ie, 30-day) mortality. The goal of this long-term follow-up was to estimate the impact of ischemic stroke on the survival of patients with AF beyond the initial 30-day period.\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003EThe Anticoagulation and Risk Factors in Atrial Fibrillation (ATRIA) Study is a cohort of 13,559 patients with diagnosed nonvalvular AF who were enrolled in an integrated health care delivery system for a median of 6 years. Incident ischemic strokes were identified using computerized databases and validated by medical record review. Functional status at discharge was obtained through chart review and was measured using a modified Rankin severity scale. Warfarin status at stroke presentation was obtained though chart review. Mortality was obtained from health plan databases and the State Death Index. The survival of patients with and without ischemic stroke was compared using multivariable Cox regression models, adjusted for clinical factors.\u003C\/p\u003E\u003Cp id=\u0022p-5\u0022\u003EA total of 1025 incident ischemic strokes, occurring over 66,717 person-years of follow-up, were identified. A comparison of baseline characteristics of the 1025 cohort members who developed stroke with 12,534 cohort members who did not develop stroke showed several significant (p\u0026lt;0.01) differences. At 5 years, \u0026gt;70% of subjects without stroke were still alive compared with fewer than 40% of those who had a stroke. Subjects who were taking warfarin at the time of their stroke had less severe strokes (44% vs 47%), lower 30-day mortality rates (19.6% vs 27.7%; p\u0026lt;0.01), and lower rates of ischemic stroke (1.2% per year vs 2%).\u003C\/p\u003E\u003Cp id=\u0022p-6\u0022\u003ECompared with cohort members without stroke, subjects who experienced a stroke had worse long-term survival (adjusted HR, 3.4; 95% CI, 3.1 to 3.7). Stroke severity at the time of discharge was a strong predictor of worse survival.\u003C\/p\u003E\u003Cp id=\u0022p-7\u0022\u003E\u201cThe effects of stroke on mortality in patients with AF persist far beyond the initial event,\u201d Dr. Fang said, noting the results of this study highlight the importance of preventing strokes and reducing the severity of strokes when they do occur.\u003C\/p\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2011 MD Conference Express\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/11\/1\/15.1.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzn4bp\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}