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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/advagg_css\/css__ce2QY63WIanKyr8eSq7eavr1XQRRmFD6ZSmwpyJi8lM__zXwFqpqmxrZOXXcd_TpBQpjuELbmIP9wBR5UuTDWAO4__YJWWMMdfCJuAFm5cUEp88OsodhO3ZA-2lzRfoBsSlk4.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003ERegardless of body mass index, patients with a higher accumulation of abdominal and liver fat have a worse cardiometabolic risk profile, according to new findings from the International Study of Prediction of Intra-Abdominal Adiposity and its Relationship with Cardiometabolic Risk\/Intra-Abdominal Adiposity [INSPIRE ME IAA].\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003ELipid Disorders\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EObesity\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ECardiometabolic Disorder\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EDiabetes \u0026amp; Endocrinology Clinical Trials\u003C\/li\u003E\u003C\/ul\u003E\u003Cp id=\u0022p-2\u0022\u003ERegardless of body mass index (BMI), patients with a higher accumulation of abdominal and liver fat have a worse cardiometabolic risk profile, according to new findings from the International Study of Prediction of Intra-Abdominal Adiposity and its Relationship with Cardiometabolic Risk\/Intra-Abdominal Adiposity (INSPIRE ME IAA).\u003C\/p\u003E\u003Cp id=\u0022p-3\u0022\u003EJean-Pierre Despr\u00e9s, PhD, Universit\u00e9 Laval, Quebec, Canada, presented results from three new INSPIRE ME IAA studies.\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003EThe INSPIRE ME IAA trial is an international imaging study that evaluated the relationship between abdominal obesity and cardiovascular disease (CVD) or type 2 diabetes. Beginning in 2006, the prospective trial enrolled 4277 patients across 29 countries and followed patients over a period of 3 years.\u003C\/p\u003E\u003Cp id=\u0022p-5\u0022\u003EAt baseline, 62% of patients had metabolic syndrome, 60% had hypertension, 39% had diabetes, and 24% had CVD. All patients underwent computed tomography (CT) imaging to measure subcutaneous and visceral adiposity and liver fat content. For both men and women, abdominal fat accumulation correlated significantly with liver fat content.\u003C\/p\u003E\u003Cp id=\u0022p-6\u0022\u003EAccording to one INSPIRE ME IAA substudy, patients with prediabetes had significantly more visceral adipose tissue (VAT) and liver fat content than patients with normal glucose metabolism [Borel AL et al. Poster #329; Nazare JA et al. Poster #426]. Of several cardiometabolic risk factors, elevated liver fat accumulation was most closely associated with impaired glucose tolerance. Therefore, even before the onset of diabetes, abdominal obesity is an indicator of elevated cardiometabolic risk.\u003C\/p\u003E\u003Cp id=\u0022p-7\u0022\u003EAnother INSPIRE ME IAA substudy evaluated the relationships between body fat distribution and patient ethnicity [Smith JD et al. INSPIRE ME IAA Poster #215]. Across all ethnicities, higher BMI was correlated significantly with greater visceral fat accumulation and liver fat content. However, compared with other ethnicities, East Asian patients were more prone to gaining visceral adipose tissue as BMI values increased. This suggests that East Asian patients begin to accumulate visceral adipose tissue at lower BMI values, putting them at higher risk for diabetes and CVD than other patients with similar BMI levels. The emerging epidemic of obesity in Asia has especially dangerous implications for cardiovascular health in that part of the world.\u003C\/p\u003E\u003Cp id=\u0022p-8\u0022\u003EINSPIRE ME IAA investigators also evaluated the potential role of statin therapy for managing cardiometabolic risk in patients with diabetes and\/or CVD. Regardless of background pharmacotherapy, diabetes and CVD were associated with higher cardiometabolic risk. Total VAT and liver fat content was higher among patients with diabetes than without diabetes (p\u0026lt;0.05) and higher among patients with CVD than without CVD (p\u0026lt;0.05). In all disease categories, patients with a higher volume of VAT and liver fat content were more likely to be on statin therapy (p\u0026lt;0.05), suggesting that physicians recognized the worse cardiovascular risk profile in these patients and treated them more aggressively (\u003Ca id=\u0022xref-fig-1-1\u0022 class=\u0022xref-fig\u0022 href=\u0022#F1\u0022\u003EFigure 1\u003C\/a\u003E). Although statin therapy addresses some CVD risk factors, including elevated cholesterol, it does not effectively manage the residual cardiometabolic risk that is associated with abdominal obesity.\u003C\/p\u003E\u003Cdiv id=\u0022F1\u0022 class=\u0022fig pos-float  odd\u0022\u003E\u003Cdiv class=\u0022highwire-figure\u0022\u003E\u003Cdiv class=\u0022fig-inline-img-wrapper\u0022\u003E\u003Cdiv class=\u0022fig-inline-img\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/11\/2\/12\/F1.large.jpg?width=800\u0026amp;height=600\u0026amp;carousel=1\u0022 title=\u0022INSPIRE ME IAA: Visceral Adipose Tissue According to Statin Therapy, Type 2 Diabetes, and CVD.\u0022 class=\u0022fragment-images colorbox-load\u0022 rel=\u0022gallery-fragment-images-969836018\u0022 data-figure-caption=\u0022INSPIRE ME IAA: Visceral Adipose Tissue According to Statin Therapy, Type 2 Diabetes, and CVD.\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003E\u003Cimg class=\u0022fragment-image\u0022 alt=\u0022Figure 1.\u0022 src=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/11\/2\/12\/F1.medium.gif\u0022\/\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cul class=\u0022highwire-figure-links inline\u0022\u003E\u003Cli class=\u00220 first\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/11\/2\/12\/F1.large.jpg?download=true\u0022 class=\u0022highwire-figure-link highwire-figure-link-download\u0022 title=\u0022Download Figure 1.\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload figure\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00221\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/11\/2\/12\/F1.large.jpg\u0022 class=\u0022highwire-figure-link highwire-figure-link-newtab\u0022 target=\u0022_blank\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EOpen in new tab\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00222 last\u0022\u003E\u003Ca href=\u0022\/highwire\/powerpoint\/12245\u0022 class=\u0022highwire-figure-link highwire-figure-link-ppt\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload powerpoint\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003Cdiv class=\u0022fig-caption attrib\u0022\u003E\u003Cspan class=\u0022fig-label\u0022\u003EFigure 1.\u003C\/span\u003E \n            \u003Cp id=\u0022p-9\u0022 class=\u0022first-child\u0022\u003EINSPIRE ME IAA: Visceral Adipose Tissue According to Statin Therapy, Type 2 Diabetes, and CVD.\u003C\/p\u003E\n         \u003Cq class=\u0022attrib\u0022 id=\u0022attrib-1\u0022\u003EReproduced with permission from JP Despr\u00e9s, PhD.\u003C\/q\u003E\u003Cdiv class=\u0022sb-div caption-clear\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cp id=\u0022p-10\u0022\u003EThe INSIPRE ME IAA study may help to redefine our understanding of obesity, which is much more complex than having a high BMI, said Prof. Despr\u00e9s. Irrespective of BMI, patients with excess abdominal fat have a worse cardiometabolic risk profile, even when managed with modern pharmacotherapy. Effective treatment may require interventions that address the specific metabolic risks that are associated with abdominal obesity.\u003C\/p\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2011 MD Conference Express\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/11\/2\/12.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_figures.js?nzn3v1\u0022\u003E\u003C\/script\u003E\n\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzn3v1\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}