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xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003EA novel platinum-chromium everolimus-eluting stent proved to be as safe and effective as the cobalt-chromium everolimus-eluting stent in the 12-month Prospective, Randomized, Multicenter Trial to Assess an Everolimus-Eluting Coronary Stent System [PROMUS Element] for the Treatment of up to Two De Novo Coronary Artery Lesions Trial [PLATINUM; \u003Ca class=\u0022external-ref external-ref-type-clintrialgov\u0022 href=\u0022\/lookup\/external-ref?link_type=CLINTRIALGOV\u0026amp;access_num=NCT00823212\u0026amp;atom=%2Fspmdc%2F11%2F3%2F15.1.atom\u0022\u003ENCT00823212\u003C\/a\u003E], the first large-scale, international, multicenter, prospective, single-blind, randomized trial of the novel stent [Stone GW et al. \u003Cem\u003EJ Am Coll Cardiol\u003C\/em\u003E 2011].\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003ECardiology Clinical Trials\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EInterventional Techniques \u0026amp; Devices\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EMyocardial Infarction\u003C\/li\u003E\u003C\/ul\u003E\u003Cp id=\u0022p-2\u0022\u003EA novel platinum-chromium everolimus-eluting stent (PtCr-EES) proved to be as safe and effective as the cobalt-chromium everolimus-eluting stent (CoCr-EES) in the 12-month Prospective, Randomized, Multicenter Trial to Assess an Everolimus-Eluting Coronary Stent System [PROMUS Element] for the Treatment of up to Two De Novo Coronary Artery Lesions Trial (PLATINUM; \u003Ca class=\u0022external-ref external-ref-type-clintrialgov\u0022 href=\u0022\/lookup\/external-ref?link_type=CLINTRIALGOV\u0026amp;access_num=NCT00823212\u0026amp;atom=%2Fspmdc%2F11%2F3%2F15.1.atom\u0022\u003ENCT00823212\u003C\/a\u003E), the first large-scale, international, multicenter, prospective, single-blind, randomized trial of the novel stent [Stone GW et al. \u003Cem\u003EJ Am Coll Cardiol\u003C\/em\u003E 2011]. The PROMUS Element drug-eluting stent (DES) uses the same biocompatible, inert fluorocopolymer and antiproliferative agent as an earlier-generation CoCr-EES (PROMUS) but has a modified scaffold that is designed to improve delivery, vessel conformability, side branch access, radiopacity, radial strength, and fracture resistance.\u003C\/p\u003E\u003Cp id=\u0022p-3\u0022\u003EIn PLATINUM, 1530 patients who were undergoing percutaneous coronary intervention (PCI) of one or two \u003Cem\u003Ede novo\u003C\/em\u003E native lesions were randomized to receive CoCr-EES (n=762) or a PtCr-EES (n=768). The primary endpoint was the 12-month rate of target lesion failure (TLF), the composite of target vessel-related cardiac death, target vessel-related myocardial infarction (MI), or ischemia-driven target lesion revascularization (TLR) in patients who received at least one assigned study stent. The trial was powered to test for a noninferiority risk difference within 3.5%. Secondary endpoints included individual components of the primary endpoint, stent thrombosis, successful delivery and deployment of the stent without balloon rupture or stent embolization, and clinical procedural success, defined as a final lesion diameter \u0026lt;30% with TIMI 3 flow.\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003EAmong the 1530 patients who were enrolled and randomized, the mean age was 63 years, 28% was female, 23% had diabetes, and 24% had unstable angina. A total of 27 of the 762 patients (3.5%) who received CoCr-EES and 23 of the 768 patients (3.0%) who received PtCr-EES were lost to follow-up or withdrew consent. At 12 months, the primary outcome of TLF had occurred in 2.9% (21 out of 714) of the CoCr-EES versus 3.4% (25\/731 patients) of the PtCr-EES group (risk difference +0.5%; 95% CI, \u22121.3 to 2.3%; p for noninferiority=0.001). Results were similar in the intention-to-treat analysis: 3.2% (23\/737) of the CoCr-EES versus 3.5% (26\/742) of the PtCr-EES group (risk difference +0.3%; 95% CI, \u22121.5% to 2.2%; p for noninferiority=0.0009). TLR and stent thrombosis rates were very rare and occurred equally with both stents (1.9% and 0.4%, respectively).\u003C\/p\u003E\u003Cp id=\u0022p-5\u0022\u003EFindings from PLATINUM indicate that along with stainless steel and cobalt chromium, platinum chromium may now be considered an acceptable metal alloy for use in DES. Of note, however, the event rates were less than expected (and similar to the number that was lost to follow-up); thus, while statistical noninferiority was demonstrated, small differences between the stents can not be excluded. Longer-term follow-up and additional multicenter studies are indicated in patients with acute coronary syndromes and\/or complex coronary anatomy to further assess stent deliverability and clinical outcomes in these important patient populations.\u003C\/p\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2011 MD Conference Express\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/11\/3\/15.1.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzn361\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}